362-03-004 ISMRM Abstract

QSM and R2* Reveal Genetic Effects on Brain Iron in Psychotic-Like Experiences

Primary: Neuro - Psychiatric Disorders

Secondary: Contrast Mechanisms - Susceptibility/QSM

362-03-004 · Neuroimaging Signatures Across the Psychiatric Spectrum · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row C

Keywords: Psychiatric Disorders Quantitative Susceptibility Mapping (QSM) R2 star UK Biobank Polygenic risk

Accepted

Marisleydis Garcia¹, Eduardo Perez-Palma², Camilo Villamán², Gabriela Repetto³, Nicolás Crossley^4,5,6, Carlos Milovic^4,7, Cristian Tejos ^4,7,8

¹Biomedical Engineering, Faculty of Engineering, Universidad de Santiago de Chile, Santiago, Chile

²Centro de Genética y Genómica, Universidad del Desarrollo, Santiago, Chile

³Center for Genetics and Genomics, Institute of Science and Innovation in Medicine, School of Medicine, Clinica Alemana Universidad del Desarrollo, Santiago, Chile

⁴Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile

⁵Department of Psychiatry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

⁶Millennium Institute for Intelligent Healthcare Engineering - iHEALTH, Santiago, Chile

⁷Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

⁸Millennium Institute Millennium Institute for Intelligent Healthcare Engineering (iHEALTH), Pontificia Universidad Católica de Chile, Santiago, Chile

Presenting Author: Cristian Tejos

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References

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2. Xu M, Guo Y, Cheng J, et al. Brain iron assessment in patients with First-episode schizophrenia using quantitative susceptibility mapping. NeuroImage Clin. 2021;31. doi:10.1016/J.NICL.2021.102736 [doi]

3. Ravanfar P, Syeda WT, Jayaram M, et al. In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia. Schizophr 2022 81. 2022;8(1):1-11. doi:10.1038/s41537-022-00293-1 [doi]

4. Shibukawa S, Kan H, Honda S, et al. Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia. Transl Psychiatry. 2024;14(1):1-8. doi:10.1038/s41398-024-02862-7 [doi]

5. Ravanfar P, Loi SM, Syeda WT, et al. Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases. Front Neurosci. 2021;15:618435. doi:10.3389/FNINS.2021.618435 [doi]

6. Barkhuizen W, Pain O, Dudbridge F, Ronald A. Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders. Transl Psychiatry. 2020;10(1):86. doi:10.1038/s41398-020-0765-2 [doi]

7. Craddock N, O’Donovan MC, Owen MJ. Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or “schizoaffective”) psychoses. Schizophr Bull. 2009;35(3):482-490. doi:10.1093/schbul/sbp020 [doi]

8. Ripke S, Neale BM, Corvin A, et al. Biological insights from 108 schizophrenia-associated genetic loci. Nat 2014 5117510. 2014;511(7510):421-427. doi:10.1038/nature13595 [doi]

9. Wang C, Martins-Bach AB, Alfaro-Almagro F, et al. Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging. Nat Neurosci 2022. Published online May 23, 2022:1-14. doi:10.1038/s41593-022-01074-w [doi]

10. Wainberg M, Jacobs GR, di Forti M, Tripathy SJ. Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank. Transl Psychiatry 2021 111. 2021;11(1):1-9. doi:10.1038/s41398-021-01330-w [doi]

11. Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: Version III - The final common pathway. Schizophr Bull. 2009;35(3):549-562. doi:10.1093/schbul/sbp006 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-03-004