Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
502-03-003 ISMRM Abstract

Pediatric normative models of subcortical grey matter nuclei with application to prenatal alcohol exposure

Primary: Analysis Methods - Segmentation and Detection
Secondary: Pediatrics - Neuro
502-03-003 · Defining "Normal" in Pediatric Brain MRI · Wednesday, 13 May, 1:40 PM–3:30 PM · Hall 1B
Keywords: Normative modeling Prenatal alcohol exposure Thalamic nuclei Multi-atlas segmentation Deep grey matter nuclei
Accepted
manojkumar saranathan1, Monisha Murali2, David Kennedy3, christian haselgrove3, Taylor Young3, Mohammed Salman Shazeeb 3, Catherine Lebel4,5
1Department of Radiology, University of Massachusetts Chan Medical School, Worcester, United States of America
2University of California, Santa Barbara, United States of America
3University of Massachusetts Chan Medical School, Worcester, United States of America
4Department of Radiology, University of Calgary, Calgary, Canada
5Alberta Children's Hospital Research Insitute, Calgary, Canada
Presenting Author: Mohammed Salman Shazeeb

Synopsis

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References

1. Marquand AF, Kia SM, Zabihi M, Wolfers T, Buitelaar JK, Beckmann CF. Conceptualizing mental disorders as deviations from normative functioning. Mol Psychiatry. 2019 Oct;24(10):1415–1424. PMCID: PMC6756106
2. Rutherford S, Barkema P, Tso IF, Sripada C, Beckmann CF, Ruhe HG, Marquand AF. Evidence for embracing normative modeling. Elife. 2023 Mar 13;12:e85082. PMCID: PMC10036120
3. Nakhid D, Patel D, McMorris CA, Gibbard WB, Tortorelli C, Pei J, Lebel C. Limbic brain subregions associated with mental health symptoms in youth with and without prenatal alcohol exposure. Alcohol Clin Exp Res (Hoboken). 2023 Nov;47(11):2033-2044. doi: 10.1111/acer.15181. Epub 2023 Sep 12. PMID: 38226747. [doi] [pmid]
4. Saranathan M, Cogliandro G, Hicks T, Patterson D, Vachha B, Hader A, Shazeeb MS, Cacciola A. Comprehensive Segmentation of Deep Grey Nuclei From Structural MRI Data. Hum Brain Mapp. 2025 Oct 1;46(14):e70350. doi: 10.1002/hbm.70350. PMID: 40985796; PMCID: PMC12455863. [doi] [pmid]
5. Young TR, Kumar VJ, Saranathan M. Normative Modeling of Thalamic Nuclear Volumes and Characterization of Lateralized Volume Alterations in Alzheimer’s Disease Versus Schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Aug 23;S2451-9022(24)00241–6. PMCID: PMC11895802

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/502-03-003