460-02-006 ISMRM Abstract

Soluble Aβ40-Mediated Neuronal Dysfunction in Alzheimer’s Disease

Primary: Neuro - Alzheimer's Disease

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

460-02-006 · From Bench to Bedside: All About the Brain in Health and Alzheimer’s Disease · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row A

Keywords: Glutamate Cerebral metabolic rate of glucose oxidation Amyloid Plaques Soluble Abeta oligomers 1H-13C-NMR

Accepted

Chaynita Dashora¹, Anant B Patel

¹NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Presenting Author: Anant B Patel

Synopsis

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References

1. Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 2014;83(1):11-26.

2. Mosconi L, Pupi A, De Leon MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer’s disease. Ann NY Acad Sci. 2009;1147:180–95.

3. Snyder, E. M. et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci. 2005; 8:1051–1058.

4. Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer’s disease. Neuron. 2014;82:756–71.

5. Oakley H, Cole SL, Logan S, Maus E et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006;26(40):10129-40.

6. Patel AB, Tiwari V, Veeraiah P, Saba K. Increased astroglial activity and reduced neuronal function across brain in AβPP-PS1 mouse model of Alzheimer's disease. J Cereb Blood Flow Metab. 2018;38(7):1213-1226.

7. Tiwari V, Ambadipudi S, Patel AB. Glutamatergic and GABAergic TCA cycle, and neurotransmitter cycling fluxes in different regions of mouse brain. J Cereb Blood Flow Metab. 2013;33(10):1523-31.

8. de Graaf RA, Brown PB, Mason GF, Rothman DL, Behar KL. Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy. Magn Reson Med. 2003;49(1):37-46.

9. Mishra PK, Kumar A, Behar KL, Patel AB. Subanesthetic ketamine reverses neuronal and astroglial metabolic activity deficits in a social defeat model of depression. J Neurochem. 2018;146(6):722-734.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-02-006