Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-04-003 ISMRM Abstract

Longitudinal Neurometabolic Mapping Reveals Brain Regional Vulnerability in Young Rats with Chronic Liver Disease

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Other Neurodegeneration
363-04-003 · From Iron to Intelligence: Quantitative Imaging and AI in Brain Disorders · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row D
Keywords: 9.4T Sex differences 1H-MRSI Preclinical Imaging Chronic Hepatic Encephalopathy
Accepted
Gianna Nossa 1,2, Brayan Alves1,2, Thanh Phong Lê1,2, Dario Sessa3, Tan Toi Phan1,2, Thi Ngoc Anh Dinh1,2, Estelle Gerossier1,2, Bernard Lanz1,2, Valerie McLin3, Cristina Cudalbu1,2
1CIBM Center for BioMedical Imaging, Lausanne, Switzerland, Switzerland
2CIBM Pre-Clinical Imaging, Lausanne, Switzerland
3Swiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland, Switzerland
Presenting Author: Gianna Nossa

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References

1. Braissant, O.; Rackayová, V.; Pierzchala, K.; Grosse, J.; McLin, V. A. V. A.; Cudalbu, C. Longitudinal Neurometabolic Changes in the Hippocampus of a Rat Model of Chronic Hepatic Encephalopathy. Journal of Hepatology 2019, 71 (3), 505–515. https://doi.org/10.1016/j.jhep.2019.05.022 [doi]
2. McLin, V. A.; D’Antiga, L. The Current Pediatric Perspective on Type B and C Hepatic Encephalopathy. Analytical Biochemistry 2022, 643, 114576.
3. Rackayova, V.; Braissant, O.; Rougemont, A. L.; Cudalbu, C.; McLin, V. A. Longitudinal Osmotic and Neurometabolic Changes in Young Rats with Chronic Cholestatic Liver Disease. Scientific Reports 2020, 10 (1), 7536. https://doi.org/10.1038/s41598-020-64416-3. [doi]
4. Simicic, D.; Pierzchala, K.; Rackayová, V.; Braissant, O.; Mitrea, S.-O.; Sessa, D.; McLin, V.; Cudalbu, C. In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy. The American Journal of Gastroenterology 2019, 114 (S17). https://doi.org/10.1016/j.ab.2022.114576. [doi]
5. DeMorrow, S.; Cudalbu, C.; Davies, N.; Jayakumar, A. R.; Rose, C. F. 2021 ISHEN Guidelines on Animal Models of Hepatic Encephalopathy. Liver International 2021, 41 (7), 1474–1488. https://doi.org/10.1111/liv.14911. [doi]
6. Simicic, D.; Alves, B.; Mosso, J.; Briand, G.; Lê, T. P.; van Heeswijk, R. B.; Starčuková, J.; Lanz, B.; Klauser, A.; Strasser, B.; Bogner, W.; Cudalbu, C. Fast High-Resolution Metabolite Mapping in the Rat Brain Using 1H-FID-MRSI at 14.1T. NMR in Biomedicine 2024, 38(2), 5304. https://doi.org/10.1002/nbm.5304 [doi]
7. Guillaume Briand; Brayan Alves; Jessie Mosso; Katarzyna Pierzchala; Jamie Near; Bernard Lanz; Cristina Cudalbu. MRS4Brain Toolbox: An Harmonized and Accessible Workflow for Preclinical MRSI Data Processing. In ISMRM 2024.

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http://echo.ismrm.org/p/ISMRM2026/363-04-003