365-01-010 ISMRM Abstract

Quantitative oxygen consumption MRI reveals improved myocardial efficiency by mavacamtem in HOCM

Primary: Cardiovascular - Heart Failure

Secondary: Contrast Mechanisms - Oxygenation

365-01-010 · Cardiomyopathies · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row F

Keywords: Blood Oxygenation Cardiac Low rank Hypertrophic obstructive cardiomyopathy Multi-parametric Quantitative Imaging

Accepted

Lujing Xing^1,2, Ruoxue Jia³, Chia Chi Yang ¹, shiqi Jin³, Li-Ting Huang^4,5, Henghui Zhang³, Ranran Zhang³, Yuheng Huang¹, Xiaoming Bi⁶, Debiao Li^1,2, Rohan Dharmakumar⁷, Guan Wang³, Ting Liu³, Hsin-Jung Yang¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America

²Department of Bioengineering, Samueli School of Engineering, University of California Los Angeles, Los Angeles, United States of America

³The First Hospital of China Medical University, Shenyang, China

⁴National Cheng Kung University, Tainan, Taiwan

⁵National Cheng Kung University Hospital, Tainan, Taiwan

⁶MR R&D Collaborations, Siemens Medical Solutions USA, Inc, Los Angeles, United States of America

⁷Indiana University School of Medicine, Indianapolis, United States of America

Presenting Author: Chia Chi Yang

Synopsis

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References

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2. Olivotto, I., Oreziak, A., Barriales-Villa, R., Abraham, T. P., Masri, A., Garcia-Pavia, P., Saberi, S., Lakdawala, N. K., Wheeler, M. T., Owens, A., Kubanek, M., Wojakowski, W., Jensen, M. K., Gimeno-Blanes, J., Afshar, K., Myers, J., Hegde, S. M., Solomon, S. D., Sehnert, A. J., Zhang, D., … EXPLORER-HCM study investigators (2020). Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (London, England), 396(10253), 759–769. https://doi.org/10.1016/S0140-6736(20)31792-X [doi]

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4. Christodoulou, A. G., Shaw, J. L., Nguyen, C., Yang, Q., Xie, Y., Wang, N., & Li, D. (2018). Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging. Nature biomedical engineering, 2(4), 215–226. https://doi.org/10.1038/s41551-018-0217-y [doi]

5. Luz, Z., and S. Meiboom. "Nuclear magnetic resonance study of the protolysis of trimethylammonium ion in aqueous solution—order of the reaction with respect to solvent." The Journal of Chemical Physics 39.2 (1963): 366-370. https://doi.org/10.1063/1.1734254 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/365-01-010