666-01-006 ISMRM Abstract

Extending the T1 lifetime of [1-13C]pyruvate to over 4 min

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Physics & Engineering - Bioeffects & Magnetic Fields

666-01-006 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G

Keywords: 1-13C Pyruvate T1 relaxation time Hyperpolarized MRI Dynamic Nuclear Polarisation Magnetic field cycling

Accepted

Josh Philipp Peters¹, Florin Teleanu^2,3, Charbel Assaf⁴, Huijing Zou³, Jan-Bernd Hövener⁴, Alexej Jerschow³, Andrey Pravdivtsev⁴

¹Section Biomedical Imaging, Dept. of Radiology and Neuroradiology, Kiel University, Kiel, Germany

²ELI-NP, “Horia Hulubei” National Institute for Physics and Nuclear Engineering, Romania

³Department of Chemistry, New York University, New York, United States of America

⁴Section Biomedical Imaging, Dept. Radiology, Kiel University, Kiel, Germany

Presenting Author: Marta M Pokotylo

Synopsis

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References

1. Nelson, S. J. et al. Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate. Science Translational Medicine 5, 198ra108-198ra108 (2013). doi: 10.1126/scitranslmed.3006070 [doi]

2. Peters, J. P. et al. Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions. Sci. Adv. 9, eadd3643 (2023). doi: 10.1126/sciadv.add3643 [doi]

3. Peters, J. et al. Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization. Sci. Adv.11, eadx2316 (2025). doi: 10.1126/sciadv.adx2316 [doi]

4. Peters, J. P. et al. Compact magnetic field cycling system with the range from nT to 9.4 T exemplified with 13C relaxation dispersion and SABRE-SHEATH hyperpolarization. Preprint (2025). doi: 10.48550/arXiv.2506.08711 . [doi]

5. Peters, J. P. et al. Over four minutes relaxation of pyruvate using chemically and physically induced deceleration of relaxation. Preprint (2025). doi: 10.48550/arXiv.2510.23244 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-006