Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-01-008 ISMRM Abstract

MR elastography-based quantitative parameters for assessing CD8+ T cell infiltration in HCC

Primary: Body - Liver
Secondary: Acquisition & Reconstruction - Non-AI methods
361-01-008 · Advanced Quantitative Liver MRI: Radiomics, Elastography, and AI · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row B
Keywords: Hepatocellular carcinoma Magnetic Resonance Elastography Tumor stiffness Shear Strain Mapping CD8
Accepted
Ying Zeng 1, Jinhui Zhou1, Ziying Yin2, Yuanqiang Xiao1, Haimei Chen1, Jiahui Li2, Emi Hojo2, Yuan Le2, Kay Pepin3, Jeremy Heilman3, Matthew C Murphy2, Jun Chen2,4, Kevin J Glaser2, Meng Yin2, Richard Ehman2, Jin Wang1
1Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2Department of Radiology, Mayo Clinic, Rochester, United States of America
3Resoundant Inc, Rochester, United States of America
4Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
Presenting Author: Ying Zeng

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References

1. Zhang, Lina et al. “The value of quantitative MR elastography-based stiffness for assessing the microvascular invasion grade in hepatocellular carcinoma.” European radiology vol. 33,6 (2023): 4103-4114. doi:10.1007/s00330-022-09290-5 [doi]
2. Zhang, Lina et al. “Three-dimensional MR elastography-based stiffness for assessing the status of Ki67 proliferation index and Cytokeratin-19 in hepatocellular carcinoma.” European radiology vol. 35,8 (2025): 4722-4735. doi:10.1007/s00330-025-11375-w [doi]
3. Hojo E, Sui Y, Shan X, Zheng K, Rossman P, Waters T, Manduca A, Powell GM, An KN, Ehman RL, Nanda S, Chon TY, Bauer BA, Yin Z. MR Elastography-Based Slip Interface Imaging for Assessment of Myofascial Interface Mobility in Chronic Low Back Pain: A Pilot Study. Magn Reson Med. 2025 Oct 24. doi: 10.1002/mrm.70158. Epub ahead of print. PMID: 41133348. [doi] [pmid]
4. Zhang, Jinjia et al. “Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor.” Cell vol. 187,13 (2024): 3409-3426.e24. doi:10.1016/j.cell.2024.04.023 [doi]
5. Mai, Zizhao et al. “Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy.” Cell death & disease vol. 15,5 307. 1 May. 2024, doi:10.1038/s41419-024-06697-4 [doi]
6. Ramzan, Muhammad et al. “Liver-infiltrating CD8(+) lymphocytes as prognostic factor for tumour recurrence in hepatitis C virus-related hepatocellular carcinoma.” Liver international : official journal of the International Association for the Study of the Liver vol. 36,3 (2016): 434-44. doi:10.1111/liv.12927 [doi]
7. Li, Mengsi et al. “MR Elastography-Based Shear Strain Mapping for Assessment of Microvascular Invasion in Hepatocellular Carcinoma.” European radiology vol. 32,7 (2022): 5024-5032. doi:10.1007/s00330-022-08578-w [doi]

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http://echo.ismrm.org/p/ISMRM2026/361-01-008