470-09-145 ISMRM Abstract

Widespread cortical diffusion MRI changes correlate with systemic inflammation in Long COVID

Primary: Diffusion - Microstructure

Secondary: Neuro - Neuroinflammation

470-09-145 · MRI in Infectious Diseases · Tuesday, 12 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall

Keywords: COVID-19 Inflammation Neurite orientation dispersion and density imaging Diffusion Tensor Imaging (DTI) Data integration

Accepted

Ana I Silva ¹, Hamza Farooq¹, Christophe Lenglet¹, James M Joers¹, Katherine Gundry¹, Alfredo Lorente¹, Jeromy Thotland¹, Dinesh K Deelchand¹, Young W Park¹, Xiufeng Li¹, Georgios E Manousakis², Abby I Metzler², Lynn Eberly³, June Kendall-Thomas⁴, Orhun H Kantarci⁴, Arvin Arani⁴, Merve Atik⁴, Matthew L Senjem⁴, Burcu Zeydan⁴, Keenan C Byrne⁵, Lauren Pollak⁶, Meher R Juttukonda⁵, David H Salat⁵, Janet C Sherman⁵, Shibani Mukerji⁷, G. Kyle Harrold⁷, Sevil Yasar⁸, Mehreen Nabi⁸, Sana Rehman⁸, Christof Karmonik⁹, Syed A. Gillani10 A Gillani⁹, Valerie Flores⁹, Rachel Davis⁹, Tetsuo Ashizawa⁹, Peter B Barker⁸, Eva-Maria Ratai⁵, Kejal Kantarci⁴, Gulin Oz¹

¹Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, United States of America

²University of Minnesota, Minneapolis, United States of America

³School of Public Health, Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, United States of America

⁴Mayo Clinic Rochester, Rochester, United States of America

⁵Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

⁶Psychology Assessment Center, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America

⁷Massachusetts General Hospital, Boston, United States of America

⁸Johns Hopkins University, Baltimore, United States of America

⁹Houston Methodist Research Institute, Houston, United States of America

Presenting Author: Ana I Silva

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References

1. (ISMRM 2025) Neurite orientation dispersion mediates effects of chronic inflammation on executive function in long-COVID. https://archive.ismrm.org/2025/3925.html.

2. Glasser, M. F. et al. The minimal preprocessing pipelines for the Human Connectome Project. NeuroImage 80, 105–124 (2013). https://doi.org/10.1016/j.neuroimage.2013.04.127 [doi]

3. Farooq, H. et al. Microstructure Imaging of Crossing (MIX) White Matter Fibers from diffusion MRI. Sci. Rep. 6, 38927 (2016). https://doi.org/10.1038/srep38927 [doi]

4. Zhang, H., Schneider, T., Wheeler-Kingshott, C. A. & Alexander, D. C. NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage 61, 1000–1016 (2012). https://doi.org/10.1016/j.neuroimage.2012.03.072 [doi]

5. Fischl, B. FreeSurfer. NeuroImage 62, 774–781 (2012). https://doi.org/10.1016/j.neuroimage.2012.01.021 [doi]

6. Greve, D. N. & Fischl, B. Accurate and robust brain image alignment using boundary-based registration. NeuroImage 48, 63–72 (2009). https://doi.org/10.1016/j.neuroimage.2009.06.060 [doi]

7. Olink Target 48. Olink® https://olink.com/products/olink-target-48.

8. Kamiya, K., Hori, M. & Aoki, S. NODDI in clinical research. J. Neurosci. Methods 346, 108908 (2020). https://doi.org/10.1016/j.jneumeth.2020.108908 [doi]

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http://echo.ismrm.org/p/ISMRM2026/470-09-145