Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
606-02-006 ISMRM Abstract

Repeatability of metabolic imaging with hyperpolarized pyruvate: back-to-back neuroimaging and blood analysis

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Contrast Mechanisms - Molecular Imaging
606-02-006 · Beyond Protons: Advances in Multinuclear and Hyperpolarized MRI · Thursday, 14 May, 1:40 PM–3:30 PM · Auditorium 2
Keywords: Hyperpolarized MR (Non-Gas) 1-13C Pyruvate Lactate 3.0T magnetic resonance imaging
Accepted
Jun Chen 1, Sung-Han Lin1, Jessica Sudderth2, Kelley Derner1, Crystal E Harrison1, Maheen Zaidi1, Jeannie D Baxter1, Jeff Liticker1, Zohreh Erfani1, Craig Malloy1,3, Marco Pinho3, Ralf J DeBerardinis2,4,5, Jae Hong Park1,3,6,7
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, United States of America
2Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States of America
3Department of Radiology, University of Texas Southwestern Medical Center, Dallas, United States of America
4Howard Hughes Medical Institute, Dallas, United States of America
5McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, United States of America
6Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, United States of America
7Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, United States of America
Presenting Author: Jun Chen

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References

1. Hurd, R.E. et al. Exchange-linked dissolution agents in dissolution-DNP (13)C metabolic imaging. Magn Reson Med 70, 936-942 (2013). DOI: 10.1002/mrm.24544 [doi]
2. Leite, T.C. et al. Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice. FEBS Lett 585, 92-98 (2011). DOI: 10.1016/j.febslet.2010.11.009 [doi]
3. Ma, J. et al. Dynamic (13) C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans. Magn Reson Med 87, 1136-1149 (2022). DOI: 10.1002/mrm.29049 [doi]
4. Ma, J. et al. Cardiac T2∗ measurement of hyperpolarized (13) C metabolites using metabolite-selective multi-echo spiral imaging. Magn Reson Med 86, 1494-1504 (2021). DOI: 10.1002/mrm.28796 [doi]
5. Chen, J. et al. Preoperative imaging of glioblastoma patients using hyperpolarized (13)C pyruvate: Potential role in clinical decision making. Neurooncol Adv 3, vdab092 (2021). DOI: 10.1093/noajnl/vdab092 [doi]
6. Park, J.M. et al. Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer. Circ Res 127, 1568-1570 (2020). DOI: 10.1161/CIRCRESAHA.120.317970 [doi]
7. Lopaschuk, G.D., Karwi, Q.G., Tian, R., Wende, A.R. & Abel, E.D. Cardiac Energy Metabolism in Heart Failure. Circ Res 128, 1487-1513 (2021). DOI: 10.1161/CIRCRESAHA.121.318241 [doi]
8. Granlund, K.L. et al. Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell Metab 31, 105-114 e103 (2020). DOI: 10.1016/j.cmet.2019.08.024 [doi]
9. Tang, S. et al. Metabolic imaging with hyperpolarized (13) C pyruvate magnetic resonance imaging in patients with renal tumors-Initial experience. Cancer 127, 2693-2704 (2021). DOI: 10.1002/cncr.33554 [doi]
10. Liu, X. et al. Initial Experience of Metabolic Imaging With Hyperpolarized [1-(13)C]pyruvate MRI in Kidney Transplant Patients. J Magn Reson Imaging 61, 1969-1978 (2025). DOI: 10.1002/jmri.29580 [doi]

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http://echo.ismrm.org/p/ISMRM2026/606-02-006