Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-02-002 ISMRM Abstract

Kurtosis time-dependence in an animal model of neuroinflammation

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - Neuroinflammation
663-02-002 · Diffusion: DWI/DTI/DKI · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row D
Keywords: Microstructure Neuroinflammation Water exchange Time-dependent diffusion MRI Diffusion kurtosis imaging
Accepted
Paulina J Villasenor 1,2, Ben N Leverton2,3,4, William Morrey2,5, Graham Coutts1,2, Ioana Mosneag1,2, Catherine Lawrence1,2, Ben Dickie2,3,5,6
1Division of Neuroscience, University of Manchester, Manchester, United Kingdom
2Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, United Kingdom
3University of Manchester, Manchester, United Kingdom
4Preclinical Imaging, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom
5Division of Informatics Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom
6Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom
Presenting Author: Paulina J Villasenor

Synopsis

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References

1. Woodburn SC, Bollinger JL, Wohleb ES. The semantics of microglia activation: neuroinflammation, homeostasis, and stress. J Neuroinflammation. 2021 Nov 6;18(1):258. doi:10.1186/s12974-021-02309-6 [doi]
2. Guglielmetti C, Veraart J, Roelant E, Mai Z, Daans J, Van Audekerke J, et al. Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination. NeuroImage. 2016 Jan 15;125:363–77. doi:10.1016/j.neuroimage.2015.10.052 [doi]
3. Zhuo J, Xu S, Proctor JL, Mullins RJ, Simon JZ, Fiskum G, et al. Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. NeuroImage. 2012 Jan;59(1):467–77. doi:10.1016/j.neuroimage.2011.07.050 [doi]
4. Praet J, Manyakov NV, Muchene L, Mai Z, Terzopoulos V, de Backer S, et al. Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology. Alzheimers Res Ther. 2018 Jan 9;10:1. doi:10.1186/s13195-017-0329-8 [doi]
5. Li H, Jiang X, Xie J, McIntyre JO, Gore JC, Xu J. Time-Dependent Influence of Cell Membrane Permeability on MR Diffusion Measurements. Magn Reson Med. 2015 Jun 11;75(5):1927. doi:10.1002/mrm.25724 [doi]
6. Aggarwal M, Smith MD, Calabresi PA. Diffusion-time dependence of diffusional kurtosis in the mouse brain. Magn Reson Med. 2020 Sep;84(3):1564–78. doi:10.1002/mrm.28189 [doi]
7. Li C, Fieremans E, Novikov DS, Ge Y, Zhang J. Measuring Water Exchange on a Preclinical MRI System using Filter Exchange and Diffusion Time Dependent Kurtosis Imaging. Magn Reson Med. 2022 Nov 20;89(4):1441. doi:10.1002/mrm.29536 [doi]
8. Maiter A, Riemer F, Allinson K, Zaccagna F, Crispin-Ortuzar M, Gehrung M, et al. Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain. Sci Rep. 2021 Apr 23;11(1):8857. doi:10.1038/s41598-021-87857-w [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-02-002