Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
370-01-003 ISMRM Abstract

Quantitative Parameter Mapping Reveals Alterations in Normal-Appearing White Matter in Multiple Sclerosis

Primary: Neuro - Multiple Sclerosis
Secondary: Neuro - White Matter
370-01-003 · All About Neuroinflammation · Monday, 11 May, 8:20 AM–9:15 AM · Traditional Posters | Exhibition Hall
Keywords: Multiple Sclerosis Relaxometry Quantitative Susceptibility Mapping (QSM) Normal-Appearing White Matter Quantitative Parameter Mapping
Accepted
Emi Sato1, Yuki Kanazawa 1, Masafumi Harada2, Yo Taniguchi3, Yuki Matsumoto2, Masahiro Takizawa3
1Kumamoto University, Chuo-Ku, Japan
2Tokushima University, Tokushima, Japan
3Fujifilm Corporation, Minato, Japan
Presenting Author: Yuki Kanazawa

Synopsis

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References

1. Fu L, Matthews PM, De Stefano N, Worsley KJ, Narayanan S, Francis GS, Antel JP, Wolfson C, Arnold DL. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain. 1998 Jan;121 ( Pt 1):103-13. doi: 10.1093/brain/121.1.103. PMID: 9549491. [doi] [pmid]
2. Taniguchi Y, Yokosawa S, Shirai T, Sato R, Amemiya T, Soutome Y, Bito Y, Ochi H. Three-dimensional Multi-parameter Mapping of Relaxation Times and Susceptibility Using Partially RF-spoiled Gradient Echo. Magn Reson Med Sci. 2023 Oct 1;22(4):459-468. doi: 10.2463/mrms.mp.2021-0045. Epub 2022 Jul 30. PMID: 35908880; PMCID: PMC10552665. [doi] [pmid]
3. Schmidt P, Gaser C, Arsic M, Buck D, Förschler A, Berthele A, Hoshi M, Ilg R, Schmid VJ, Zimmer C, Hemmer B, Mühlau M. An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis. Neuroimage. 2012 Feb 15;59(4):3774-83. doi: 10.1016/j.neuroimage.2011.11.032. Epub 2011 Nov 18. PMID: 22119648. [doi] [pmid]
4. Kanazawa Y, Harada M, Taniguchi Y, Hayashi H, Abe T, Otomo M, Matsumoto Y, Ono M, Ito K, Bito Y, Haga A. Myelin-weighted imaging derived from quantitative parameter mapping. Eur J Radiol. 2022 Nov;156:110525. doi: 10.1016/j.ejrad.2022.110525. Epub 2022 Sep 16. PMID: 36166986. [doi] [pmid]
5. Kitano S, Kanazawa Y, Harada M, Taniguchi Y, Hayashi H, Matsumoto Y, Ito K, Bito Y, Haga A. Conversion map from quantitative parameter mapping to myelin water fraction: comparison with R1·R2* and myelin water fraction in white matter. MAGMA. 2024 Oct;37(5):887-898. doi: 10.1007/s10334-024-01155-w. Epub 2024 Apr 6. PMID: 38581455. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/370-01-003