Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
305-04-008 ISMRM Abstract

Conventional and in-magnet cardiopulmonary exercise testing of patients with neuromuscular disease

Primary: Musculoskeletal - Muscle
Secondary: Musculoskeletal - Functional/Dynamic
305-04-008 · MRI of Musculoskeletal Kinematics, Biomechanics, and Exercise · Monday, 11 May, 4:10 PM–6:00 PM · Ballroom West
Accepted
Melissa T Hooijmans 1,2, Eric L Voorn3, Joost Raaphorst4, Nicol Voermans5, Fieke S Koopman3, Gustav J Strijkers6, Jeroen A Jeneson2,7, Aart J Nederveen8,9
1Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
2Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
3Department of Rehabilitation Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
4Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
5Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands
6Biomedical Engineering & Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
7Center for Child Development and Exercise, Wilhelmina Children’s Hospital, Division of Child Health, University Medical Center Utrecht, Utrecht, Netherlands
8Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
9Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
Presenting Author: Melissa T Hooijmans

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References

1. Rapin A, Etosse A, Tambosco L, Nicomette J, Percebois-Macadre L, Mouret P, & Boyer FC (2013). Aerobic capacities and exercise tolerance in neuromuscular diseases: a descriptive study. Annals of phys and rehab med, 56(6), 420-433. doi: 10.1016/j.rehab.2013.04.004 [doi]
2. Hooijmans MT, Jeneson JAl, Jorstad HT, Bakermans AJ. Exercise MR of Skeletal Muscles, the Heart and the Brain. J Magn Reson Imaging. 2025 feb;61(2):535-560. Doi:10.1002/jmri.29445 [doi]
3. Bakermans, AJ, Wessel CH, Zheng KH, Groot PFC, Stroess ESG, Nederveen AJ (2020). Dynamic magnetic resonance measurements of calf muscle oxygenation and energy metabolism in peripheral artery disease. Journal of Magn Reson Imagign, 51(1), 98-197. doi: 10.1002/jmri.26841. [doi]
4. Habets LE, Bartels B Asselman F et al. Magnetic resonance reveals mitochondrial dysfunction and muscle remodeling in spinal muscular atrophy. Brain. 2022 May 24;(145(4):1422-1435. Doi: 10.1093/brain/awab411. [doi]
5. Wary C, Nadaj-Pakleza A, Laforêt P, et al. Investigating glycogenosis type III patients with multi-parametric functional NMR imaging and spectroscopy. Neuromuscul Disord. 2010 Aug;20(8):548-58. doi: 10.1016/j.nmd.2010.06.011. [doi]
6. van Brussel M., van Oorschot J.W.M., Schmitz J.P.J et al. Muscle Metabolic Responses During Dynamic In-Magnet Exercise Testing: A Pilot Study in Children with an Idiopathic Inflammatory Myopathy. Acad Radiol. 2015 Nov;22(11):1443-8. doi: 10.1016/j.acra.2015.06.013. [doi]
7. Stefan D, Cesare FD, Andrasescu A, et al.Quantitation of magnetic resonance spectroscopy signals:the jMRUI software package. Meas Sci Technol; 2009; 20:1–9. DOI: 10.1088/0957-0233/20/10/104035 [doi]
8. Paul A. Yushkevich, Joseph Piven, Heather Cody Hazlett, et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. Neuroimage 2006 Jul 1;31(3):1116-28. doi: 10.1016/j.neuroimage.2006.01.015. [doi]
9. Liu A, Niu F, Chang L, Zhang B, Liu Z, Chen Y, Zhou Q, Wu H, Xu Y. High cytochrome c oxidase expression links to severe skeletal energy failure by 31P-MRS spectroscopy in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. CNS Neurosci Ther. 2014 Jun;20(6):509-14. doi: 10.1111/cns.12257 [doi]
10. Kornblum C., Schroder R., Muller K. et al. Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study. Eur J Neuro9l. 2005 Apr;12(4):300-9. doi: 10.1111/j.1468-1331.2004.00970.x [doi]
11. Barbiroli B., Lotti S., Lodi R. Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. Biofactors. 1999;9(2-4);253-60. doi: 10.1002/biof.5520090221. [doi]
12. Oldfors-Hedberg C, Mitochondrial DNA variants in inclusion body myositis characterized by deep sequencing. Brain pathology 2020. DOI: 10.1111/bpa.12931 [doi]
13. Naddaf E., Barohn RJ, Dimachkie M. Inclusion Body Myositis: Update on Pathogenesis and Treatment. Neurotherapeutics. 2018 Oct;15(4):995-1005. doi: 10.1007/s13311-018-0658-8. [doi]
14. Müller-Höcker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J Neurol Sci. 1990 Dec;100(1-2):14-21. doi: 10.1016/0022-510x(90)90006-9. [doi]

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http://echo.ismrm.org/p/ISMRM2026/305-04-008