Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026
· Cape Town, South Africa
366-01-002
ISMRM Abstract
Voxel-wise oxygen extraction fraction mapping tracks cognition and longitudinal change in cerebral small vessel disease
Primary:
Neuro - Stroke and Cerebrovascular Disorders
Secondary:
Neuro - Dementia
366-01-002 · Cerebral Small Vessel Disease: Imaging Biomarkers, Pathophysiology, and Clinical Impact
· Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row G
Chaofan Sui 1, Meng Li2, Qihao Zhang3, Kelly M Gillen3, Jing Li4, Changhu Liang5, Lingfei Guo5, Junfang Xian1
1Beijing Tongren Hospital, Beijing, China
2Jena University Hospital, Jena, Germany
3Weill Cornell Medical College, New York, United States of America
4Beijing Tsinghua Changgung Hospital, Beijing, China
5Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
Presenting Author: Chaofan Sui
Synopsis
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1. Duering M, Biessels GJ, Brodtmann A, et al. Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurol. Jul 2023;22(7):602-618. doi:10.1016/s1474-4422(23)00131-x [doi]
2. Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. May 2011;7(3):270-9. doi:10.1016/j.jalz.2011.03.008 [doi]
3. Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health. Dec 2020;5(12):e661-e671. doi:10.1016/s2468-2667(20)30185-7 [doi]
4. Gupta A, Baradaran H, Schweitzer AD, et al. Oxygen extraction fraction and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis. AJNR Am J Neuroradiol. Feb 2014;35(2):250-5. doi:10.3174/ajnr.A3668 [doi]
5. Wang Y, Liu T. Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker. Magn Reson Med. Jan 2015;73(1):82-101. doi:10.1002/mrm.25358 [doi]
6. He X, Yablonskiy DA. Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default state. Magn Reson Med. Jan 2007;57(1):115-26. doi:10.1002/mrm.21108 [doi]
7. Cho J, Kee Y, Spincemaille P, et al. Cerebral metabolic rate of oxygen (CMRO(2) ) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level-dependent imaging (qBOLD). Magn Reson Med. Oct 2018;80(4):1595-1604. doi:10.1002/mrm.27135 [doi]
8. Zhang J, Zhou D, Nguyen TD, Spincemaille P, Gupta A, Wang Y. Cerebral metabolic rate of oxygen (CMRO(2) ) mapping with hyperventilation challenge using quantitative susceptibility mapping (QSM). Magn Reson Med. May 2017;77(5):1762-1773. doi:10.1002/mrm.26253 [doi]
9. Stevenson-Hoare J, Heslegrave A, Leonenko G, et al. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain. Feb 13 2023;146(2):690-699. doi:10.1093/brain/awac128 [doi]
10. Cho J, Zhang S, Kee Y, et al. Cluster analysis of time evolution (CAT) for quantitative susceptibility mapping (QSM) and quantitative blood oxygen level-dependent magnitude (qBOLD)-based oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO(2) ) mapping. Magn Reson Med. Mar 2020;83(3):844-857. doi:10.1002/mrm.27967 [doi]
11. Ter Telgte A, van Leijsen EMC, Wiegertjes K, Klijn CJM, Tuladhar AM, de Leeuw FE. Cerebral small vessel disease: from a focal to a global perspective. Nat Rev Neurol. Jul 2018;14(7):387-398. doi:10.1038/s41582-018-0014-y [doi]
12. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol. Jul 2019;18(7):684-696. doi:10.1016/s1474-4422(19)30079-1 [doi]
13. Cho J, Lee J, An H, Goyal MS, Su Y, Wang Y. Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with (15)O PET in healthy adults. J Cereb Blood Flow Metab. Jul 2021;41(7):1658-1668. doi:10.1177/0271678x20973951 [doi]
14. Kaczmarz S, Hyder F, Preibisch C. Oxygen extraction fraction mapping with multi-parametric quantitative BOLD MRI: Reduced transverse relaxation bias using 3D-GraSE imaging. Neuroimage. Oct 15 2020;220:117095. doi:10.1016/j.neuroimage.2020.117095 [doi]
15. Chiang GC, Cho J, Dyke J, et al. Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals. J Neuroimaging. Jul 2022;32(4):697-709. doi:10.1111/jon.12990 [doi]