Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
603-01-004 ISMRM Abstract

Cerebral “dirty-appearing” white matter is not linked to cognitive decline and dementia risk in older adults

Primary: Neuro - Dementia
Secondary: Neuro - White Matter
603-01-004 · Dementia Not Related to Alzheimer's Disease · Thursday, 14 May, 8:30 AM–10:20 AM · Auditorium 1
Keywords: Aging Dementia Cerebral small vessel disease FLAIR Imaging Cognitive decline
Accepted
Ingmar Eiling 1, Sigurdur Sigurdsson2, Jasmin A Kuhn-Keller1, Simon P Mooijaart3,4, Lenore J Launer5, Matthias van Osch1, Vilmundur Gudnason2,6, Jeroen de Bresser7
1C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
2Icelandic Heart Association, Kopavagur, Iceland
3Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
4LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, Netherlands
5Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Maryland, United States of America
6Faculty of Medicine, University of Iceland, Reykjavik, Iceland
7Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
Presenting Author: Ingmar Eiling

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References

1. 1. Eiling I, Sigurdsson S, Verweg L, et al. The association between cerebral "dirty-appearing" white matter and progression of small vessel disease in community-dwelling older adults. J Cereb Blood Flow Metab 2025; 0:0. DOI: 10.1177/0271678X251385591. [doi]
2. 2. Cairns J, Vavasour IM, Traboulsee A, et al. Diffusely abnormal white matter in multiple sclerosis. J Neuroimaging 2022; 32: 5–16. 20211109. DOI: 10.1111/jon.12945. [doi]
3. 4. Harris TB, Launer LJ, Eiriksdottir G, et al. Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol 2007; 165: 1076–1087. 20070310. DOI: 10.1093/aje/kwk115. [doi]
4. 5. Saczynski JS, Sigurdsson S, Jonsdottir MK, et al. Cerebral infarcts and cognitive performance: Importance of location and number of infarcts. Stroke 2009; 40: 677–682. DOI: 10.1161/STROKEAHA.108.530212. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/603-01-004