Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
666-03-004 ISMRM Abstract

Investigating the Impact of Aquaporin-4 Facilitation on Glymphatic Transport After Chronic Hypoperfusion in Rats

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods
Secondary: Neuro - Neurotherapeutics
666-03-004 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G
Keywords: Glymphatic system DCE-MRI Aquaporin-4 Cerebral hypoperfusion TGN-073
Accepted
Maqbool S Al Hasani 1,2, Alaa Alghanimy1,3, Lindsay Gallagher1, Lorraine Work4, William Holmes1
1School of Psychology and Neuroscience, University of Glasgow, Glasgow, Scotland, United Kingdom
2Medical Imaging Department, Heath Science Program, Oman College of Health Science, Muscat, Sultanate of Oman, Muscat, Oman
3King Saud University, Riyadh, Saudi Arabia,Radiological Sciences Department, College of Applied Medical Sciences, Riyadh, Saudi Arabia
4Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom
Presenting Author: Maqbool S Al Hasani

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References

1. Yang, Y., Kimura-Ohba, S., Thompson, J. & Rosenberg, G. A. Rodent Models of Vascular Cognitive Impairment. Transl Stroke Res 7, 407-414 (2016). https://doi.org/10.1007/s12975-016-0486-2 [doi]
2. Duncombe, J. et al. Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia. Clinical Science 131, 2451-2468 (2017). https://doi.org/10.1042/cs20160727 [doi]
3. Shibata, M., Ohtani, R., Ihara, M. & Tomimoto, H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke 35, 2598-2603 (2004). https://doi.org/10.1161/01.Str.0000143725.19053.60 [doi]
4. Li, N. et al. A modified bilateral carotid artery stenosis procedure to develop a chronic cerebral hypoperfusion rat model with an increased survival rate. J Neurosci Methods 255, 115-121 (2015). https://doi.org/10.1016/j.jneumeth.2015.08.002 [doi]
5. Weng, Z. et al. A Novel Needle Mouse Model of Vascular Cognitive Impairment and Dementia. J Neurosci 43, 7351-7360 (2023). https://doi.org/10.1523/jneurosci.0282-23.2023 [doi]
6. Li, M. et al. Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment. Front Aging Neurosci 13, 788519 (2021). https://doi.org/10.3389/fnagi.2021.788519 [doi]
7. Alghanimy, A., Martin, C., Gallagher, L. & Holmes, W. M. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PLoS One 18, e0282955 (2023). https://doi.org/10.1371/journal.pone.0282955 [doi]

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http://echo.ismrm.org/p/ISMRM2026/666-03-004