Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
370-03-020 ISMRM Abstract

Resting-State fMRI Reveals Altered Neurofluid Dynamics and Links to Brain Fog in Neurological Post-COVID Syndrome

Primary: Neuro - Neurofluids
Secondary: Neuro - Infectious Disease
370-03-020 · Brain Functional Methods · Monday, 11 May, 9:15 AM–10:10 AM · Traditional Posters | Exhibition Hall
Keywords: Glymphatic system (GS) Brain Fog PASC
Accepted
Xinlan Zhang1, Jia Ying1,2, Zennur Sekendiz3, Ashley Fontana3, Xiaohua Yang3, Steven West3, Paul Vaska2,4, Sean A Clouston5,6, Benjamin Luft3, Chuan Huang1
1Radiology & Imaging Sciences, Emory University, Atlanta, United States of America
2Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, United States of America
3Department of Medicine, Division on Infectious Diseases, State University of New York at Stony Brook, Stony Brook, United States of America
4Radiology, State University of New York at Stony Brook, Stony Brook, United States of America
5Program in Public Health, State University of New York at Stony Brook, Stony Brook, United States of America
6Department of Family, Population, and Preventive Medicine, State University of New York at Stony Brook, Stony Brook, United States of America
Presenting Author: Sixuan Guo

Synopsis

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References

1. Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601-615. doi:10.1038/s41591-021-01283-z [doi]
2. Fultz NE, Bonmassar G, Setsompop K, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019;366(6465):628-631. doi:10.1126/science.aax5440 [doi]
3. Clouston SAP, Hall CB, Kritikos M, et al. Cognitive impairment and World Trade Centre-related exposures. Nat Rev Neurol. 2022;18(2):103-116. doi:10.1038/s41582-021-00576-8 [doi]
4. Clouston SAP, Kotov R, Pietrzak RH, et al. Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. Alzheimers Dement (Amst). 2016;4:67-75. doi:10.1016/j.dadm.2016.08.001 [doi]
5. Clouston SAP, Mann FD, Meliker J, et al. Incidence of Dementia Before Age 65 Years Among World Trade Center Attack Responders. JAMA Netw Open. 2024;7(6):e2416504. doi:10.1001/jamanetworkopen.2024.16504 [doi]
6. Hua L, Zeng X, Zhang K, Zhao Z, Yuan Z. Reduced glymphatic clearance in early psychosis. Mol Psychiatry. 2025;30(10):4665-4676. doi:10.1038/s41380-025-03058-1 [doi]
7. Han F, Chen J, Belkin-Rosen A, et al. Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology. PLOS Biology. 2021;19(6):e3001233. doi:10.1371/journal.pbio.3001233 [doi]
8. Han F, Liu X, Yang Y, Liu X. Sex-specific age-related differences in cerebrospinal fluid clearance assessed by resting-state functional magnetic resonance imaging. NeuroImage. 2024;302:120905. doi:10.1016/j.neuroimage.2024.120905 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/370-03-020