Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-05-001 ISMRM Abstract

Predicting cardiac magnetostimulation thresholds in 56 realistic body models and 13 clinical gradient systems

Primary: Physics & Engineering - Safety
Secondary: Physics & Engineering - Bioeffects & Magnetic Fields
468-05-001 · Safety · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row I
Keywords: Cardiac stimulation Gradient safety Magnetic stimulation Electromagnetic simulations
Accepted
Valerie Klein 1,2, Mathias Davids1, Natalie G Ferris1,3, Jonathan Edmonson4, Matthias Gebhardt5, Dominik Rattenbacher5, Johan van den Brink6, Michael Steckner7, Lawrence L Wald1,2,3, Bastien Guerin1,2
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
2Harvard Medical School, Boston, United States of America
3Harvard-MIT Health Sciences and Technology, Cambridge, United States of America
4Medtronic Cardiac Rhythm Management, Minneapolis, United States of America
5Siemens Healthineers AG, Erlangen, Germany
6Philips Healthcare, Best, Netherlands
7MKS Consulting, Beachwood, United States of America
Presenting Author: Valerie Klein

Synopsis

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References

1. IEC, International standard IEC 60601 medical electrical equipment. Part 2-33: Particular requirements for the basic safety and essential performance of magnetic resonance equipment for medical diagnosis. 2022, International Electrotechnical Commission (IEC).
2. Reilly J P, Principles of nerve and heart excitation by time-varying magnetic fields. Ann. N. Y. Acad. Sci., 1992. 649: 96-117.
3. Klein V, Davids M, Schad L R, Wald L L, and Guérin B, Investigating cardiac stimulation limits of MRI gradient coils using electromagnetic and electrophysiological simulations in human and canine body models. Magn. Reson. Med., 2021. 85: 1047–1061.
4. Klein V, Coll-Font J, Vendramini L, Straney D, Davids M, Ferris N G, Schad L R, Sosnovik D E, Nguyen C T, Wald L L, and Guérin B, Measurement of magnetostimulation thresholds in the porcine heart. Magn. Reson. Med., 2022. 88: 2242-2258.
5. Klein V, Davids M, Vendramini L, Ferris N G, Schad L R, Sosnovik D E, Nguyen C T, Wald L L, and Guerin B, Prediction of experimental cardiac magnetotimulation thresholds using pig-specific body models. Magn Reson Med, 2023. 90: 1594-1609.
6. Segars W P, Sturgeon G, Mendonca S, Grimes J, and Tsui B M W, 4D XCAT phantom for multimodality imaging research. Med. Phys., 2010. 37(9): 4902-4915.
7. Hasgall P A, Di Gennaro F, Baumgartner C, Gosselin M C, Payne D, Klingenböck A, and Kuster N, IT’IS Database for thermal and electromagnetic parameters of biological tissues Version 4.0. 2018. (DOI: 10.13099/VIP21000-04-0) [doi]
8. Ijiri T, Ashihara T, Yamaguchi T, Takayama K, Igarashi T, Shimada T, Namba T, Haraguchi R, and Nakazawa K, A procedural method for modeling the Purkinje fibers of the heart. J Physiol. Sci., 2008. 58(7): 481-486.
9. Anderson R H, Andrej J, Barker A, Bramwell J, Camier J S, Cerveny J, Dobrev V, Dudouit Y, Fisher A, Kolev T, Pazner W, Stowell M, Tomov V, Akkerman I, Dahm J, Medina D, and Zampini S, MFEM: A modular finite element methods library. Comput Math with Appl, 2021. 81: 42-74.
10. Stewart P, Aslanidi O V, Noble D, Noble P J, Boyett M R, and Zhang H, Mathematical models of the electrical action potential of Purkinje fibre cells. Phil. Trans. R. Soc. A, 2009. 367: 2225-2255.
11. Reilly J P, Electrical stimulation and electropathology. 1992, Cambridge: Cambridge University Press.
12. Lapicque L, Definition expérimentale de l’excitabilité. Comptes Rendus Acad. Sci., 1909. 67(2): 208-283.
13. Klein V, Edmonson J, Davids M, Ferris N G, Gebhardt M, Rattenbacher M, van den Brink J S, Steckner M, Wald L L, and Guerin B, Simulation of dB/dt-over-electric field cardiac magnetostimulation safety ratios in 75 body models and 18 gradient systems. Magn. Reson. Med., 2025: (accepted). (DOI: https://doi.org/10.1002/mrm.70130) [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-05-001