Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
405-04-004 ISMRM Abstract

Characterizing the diffusion properties of prostate epithelium across Gleason grades using MR microscopy

Primary: Diffusion - Diffusion Modeling
Secondary: Body - Prostate
405-04-004 · From Diffusion Characteristics Toward Clinical Impact · Tuesday, 12 May, 4:00 PM–5:50 PM · Ballroom West
Keywords: Diffusion Modeling Diffusion MRI Prostate cancer MR Microscopy 16.4T
Accepted
Adam Phipps 1, Nyoman D Kurniawan2, Geoffrey Watson3, Paul Sved4, Samson Dowland4, Marta Masramon5, Eleftheria Panagiotaki5, David Atkinson 1, Roger Bourne6
1Centre for Medical Imaging, Division of Medicine, University College London, London, United Kingdom
2Australian Institute for Bioengineering and Nanotechnology, Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia
3New South Wales Health Pathology, Sydney, Australia
4School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
5Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom
6Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
Presenting Author: Adam Phipps

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References

1. Delahunt B, Miller RJ, Srigley JR, Evans AJ, Samaratunga H. Gleason grading: Past, present and future. Histopathology. 2012;60(1):75-86. doi:10.1111/j.1365-2559.2011.04003.x [doi]
2. Panagiotaki E, Chan RW, Dikaios N, et al. Microstructural Characterization of Normal and Malignant Human Prostate Tissue With Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours Magnetic Resonance Imaging. Invest Radiol. 2015;50(4):218-227. doi:10.1097/RLI.0000000000000115 [doi]
3. Brunsing RL, Schenker-Ahmed NM, White NS, et al. Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI. Journal of Magnetic Resonance Imaging. 2017;45(2):323-336. doi:10.1002/jmri.25419 [doi]
4. Chatterjee A, Bourne RM, Wang S, et al. Diagnosis of Prostate Cancer with Noninvasive Estimation of Prostate Tissue Composition by Using Hybrid Multidimensional MR Imaging: A Feasibility Study. Radiology. 2018;287(3):863-873. doi:10.1148/radiol.2018171130 [doi]
5. Bourne R, Kurniawan N, Cowin G, Sved P, Watson G. 16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings. Magn Reson Med. 2011;66(1):244-247. doi:10.1002/mrm.22778 [doi]
6. Bailey C, Bourne RM, Siow B, et al. VERDICT MRI validation in fresh and fixed prostate specimens using patient-specific moulds for histological and MR alignment. NMR Biomed. 2019;32(5). doi:10.1002/nbm.4073 [doi]
7. Chatterjee A, Watson G, Myint E, Sved P, McEntee M, Bourne R. Changes in epithelium, stroma, and lumen space correlate more strongly with gleason pattern and are stronger predictors of prostate ADC changes than cellularity metrics1. Radiology. 2015;277(3):751-762. doi:10.1148/radiol.2015142414 [doi]
8. Chatterjee A, Mercado C, Bourne RM, et al. Validation of Prostate Tissue Composition by Using Hybrid Multidimensional MRI: Correlation with Histologic Findings. Radiology. 2022;302(2):368-377. doi:10.1148/radiol.2021204459 [doi]
9. Enríquez-Mier-y-Terán FE, Chatterjee A, Antic T, Oto A, Karczmar G, Bourne R. Multi-model sequential analysis of MRI data for microstructure prediction in heterogeneous tissue. Sci Rep. 2023;13(1). doi:10.1038/s41598-023-43329-x [doi]
10. Alyami W, Kyme A, Bourne R. Histological Validation of MRI: A Review of Challenges in Registration of Imaging and Whole-Mount Histopathology. Journal of Magnetic Resonance Imaging. 2022;55(1):11-22. doi:10.1002/jmri.27409 [doi]
11. Merboldt K ‐D, Hänicke W, Frahm J. Diffusion imaging using stimulated echoes. Magn Reson Med. 1991;19(2):233-239. doi:10.1002/mrm.1910190208 [doi]
12. Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: The quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005;53(6):1432-1440. doi:10.1002/mrm.20508 [doi]
13. Panagiotaki E, Schneider T, Siow B, Hall MG, Lythgoe MF, Alexander DC. Compartment models of the diffusion MR signal in brain white matter: A taxonomy and comparison. Neuroimage. 2012;59(3):2241-2254. doi:10.1016/j.neuroimage.2011.09.081 [doi]

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http://echo.ismrm.org/p/ISMRM2026/405-04-004