3Service of Clinical Chemistry, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
4Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
Presenting Author: Eloise Mougel
Synopsis
Motivation:
Goals:
Approach:
Results:
Full abstract & presentation
The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.
Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.
To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.
1. Braissant O, Henry H, Villard AM, et al. Ammonium-Induced Impairment of Axonal Growth Is Prevented through Glial Creatine. J Neurosci. 2002;22(22):9810. doi:10.1523/JNEUROSCI.22-22-09810.2002 [doi]
2. Hanna-El-Daher L, Béard E, Henry H, Tenenbaum L, Braissant O. Mild guanidinoacetate increase under partial guanidinoacetate methyltransferase deficiency strongly affects brain cell development. Neurobiology of Disease. 2015;79:14-27. doi:10.1016/j.nbd.2015.03.029 [doi]
3. Nikolaeva T, Hennink JS, Singer R, et al. Ultra-high field MRI and spatially resolved spectroscopy of organoids at 28.2 T. In: Proceedings of the 18th ICMRM. 2025.
4. Castilla Bolanos MA, Chinchalongporn V, Biswas RG, et al. Metabolic analysis in intact human-derived cerebral organoids by high-resolution magic-angle spinning NMR spectroscopy. bioRxiv. Published online January 1, 2024:2024.06.21.599412. doi:10.1101/2024.06.21.599412 [doi]
5. Honegger P. Aggregating Neural Cell Cultures. Current Protocols in Toxicology. 2003;15(1):12.9.1-12.9.17. doi:10.1002/0471140856.tx1209s15 [doi]
6. Sapcariu SC, Kanashova T, Weindl D, Ghelfi J, Dittmar G, Hiller K. Simultaneous extraction of proteins and metabolites from cells in culture. MethodsX. 2014;1:74-80. doi:10.1016/j.mex.2014.07.002 [doi]
7. Ligneul C, Palombo M, Valette J. Metabolite diffusion up to very high b in the mouse brain in vivo: Revisiting the potential correlation between relaxation and diffusion properties. Magnetic Resonance in Medicine. 2017;77(4):1390-1398. doi:10.1002/mrm.26217 [doi]
8. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR in Biomedicine. 2001;14(4):260-264. doi:10.1002/nbm.698 [doi]
9. Oliveira R, Brammerloh M. dMRSI pipeline. Git Hub - dMRSI. Accessed October 25, 2025. https://github.com/rita-o/dMRSI/tree/main
10. Lanz B, Abaei A, Braissant O, et al. Magnetic resonance spectroscopy in the rodent brain: Experts’ consensus recommendations. NMR in Biomedicine. 2021;34(5):e4325. doi:10.1002/nbm.4325 [doi]
11. Urzì C, Hertig D, Meyer C, Maddah S, Nuoffer JM, Vermathen P. Determination of Intra- and Extracellular Metabolic Adaptations of 3D Cell Cultures upon Challenges in Real-Time by NMR. IJMS. 2022;23(12):6555. doi:10.3390/ijms23126555 [doi]