Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-01-008 ISMRM Abstract

Hidden Layers of Learning: SANDI Reveals CA3 Microstructural Plasticity Following Route Learning

Primary: Neuro - Gray Matter
Secondary: Diffusion - Microstructure
363-01-008 · Neurological Application of Advanced Diffusion and Quantitative MRI · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: Neuroplasticity Ultra-strong gradients SANDI model Hippocampal subfields Route learning
Accepted
Katie Smith 1, Derek K Jones2, Mia Winter3,4, Bradley G Karat5, Carolyn McNabb2
1Cardiff Univeristy Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
3Cardiff and Vale University Health Board, Cardiff, United Kingdom
4Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
5The Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, United States of America
Presenting Author: Katie Smith

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References

1. Maguire EA, Gadian DG, Johnsrude IS, et al. (2000) Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci USA 97:4398–4403. doi: 10.1073/pnas.070039597 [doi]
2. Sagi Y, Tavor I, Pietrini P, Cappa SF, Ben-Bashat D, Le Bihan D, Assaf Y (2012) Learning in the fast lane: new insights into neuroplasticity. Science 335:1518–1521. doi: 10.1016/j.neuron.2012.01.025 [doi]
3. Hofstetter S, Tavor I, Tzur-Moryosef S, Assaf Y (2013) Short-term learning induces white matter plasticity in the fornix. Nat Commun 4:2128. doi: 10.1523/JNEUROSCI.4520-12.2013 [doi]
4. Tavor I, Hofstetter S, Assaf Y (2013) Micro-structural assessment of short-term plasticity dynamics. NeuroImage 81:1–7. doi: 10.1016/j.neuroimage.2013.05.050 [doi]
5. Palombo M, Ianus A, Guerreri M, Nunes D, Alexander DC, Shemesh N, Zhang H (2020) SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI. NeuroImage 215:116835. doi: 10.1016/j.neuroimage.2020.117612 [doi]
6. DeKraker J, Haast RAM, Yousif MD, Karat B, Lau JC, Köhler S, Khan AR (2022) Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold. eLife 11:e77945. doi: 10.7554/eLife.77945 [doi]
7. McNabb CB, Driver ID, Hyde V, et al. (2025) WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis. Sci Data 12:220. doi: 10.1038/s41597-024-04154-7 [doi]
8. Christiansen K, Aggleton JP, Parker GD, O’Sullivan MJ, Metzler-Baddeley C (2016) Topographic separation of fornical fibers associated with the anterior and posterior hippocampus in the human brain: an MRI-diffusion study. Brain Struct Funct 221:4221–4237. doi: 10.1002/brb3.604 [doi]
9. Sled JG, Pike GB (2001) Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI. J Magn Reson 148:31–40. doi: 10.1002/mrm.1278 [doi]

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http://echo.ismrm.org/p/ISMRM2026/363-01-008