431-02-003 / 431-02-003 ISMRM Abstract

Urea CEST MRI provides insights into renal cyst physiology

Primary: Contrast Mechanisms - CEST / APT / NOE

Secondary: Body - Kidney

431-02-003 · A Clearer View Within: Advances in Body Imaging · Tuesday, 12 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: Ultra-high field CEST MRI Kidney MRI Renal Cyst Urea

Accepted

Petr Bulanov ^1,2, Christian Neelsen³, Petr Menshchikov¹, Philip S Boyd¹, Mark E Ladd^1,2,4, Andreas Korzowski¹, Sebastian Schmitter^1,5,6, Johan M Jende³

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

²Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany

³Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

⁴Faculty of Medicine, Heidelberg University, Heidelberg, Germany

⁵Center for Magnetic Resoance Research, University of Minnesota, Minneapolis, United States of America

⁶Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany

Presenting Author: Petr Bulanov

Synopsis

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References

1. Hélénon O, Crosnier A, Verkarre V, Merran S, Méjean A, Correas JM. Simple and complex renal cysts in adults: Classification system for renal cystic masses. Diagnostic and Interventional Imaging. 2018;99(4):189-218. doi:10.1016/j.diii.2017.10.005 [doi]

2. Bisceglia M, Galliani CA, Senger C, Stallone C, Sessa A. Renal cystic diseases: a review. Adv Anat Pathol. 2006;13(1):26-56. doi:10.1097/01.pap.0000201831.77472.d3 [doi]

3. Dagher AP, Aletras A, Choyke P, Balaban RS. Imaging of urea using chemical exchange-dependent saturation transfer at 1.5T. J Magn Reson Imaging. 2000;12(5):745-748. doi:10.1002/1522-2586(200011)12:5<745::aid-jmri12>3.0.co;2-h [doi]

4. Elena Vinogradov, Zheng Liu, , Ananth Madhuranthakam, Asghar Hajibeigi, , Adrien Jump, , Ivan Pedrosa, Orson W Moe, , and Robert E Lenkinski. Endogenous Urea CEST (urCEST) for MRI monitoring of kidney function. Proc Intl Soc Mag Reson Med 23 (2015).

5. Shin SH, Wendland MF, Zhang B, Tran A, Tang A, Vandsburger MH. Noninvasive imaging of renal urea handling by CEST-MRI. Magn Reson Med. 2020;83(3):1034-1044. doi:10.1002/mrm.27968 [doi]

6. Stabinska J, Neudecker P, Ljimani A, Wittsack HJ, Lanzman RS, Müller-Lutz A. Proton exchange in aqueous urea solutions measured by water-exchange (WEX) NMR spectroscopy and chemical exchange saturation transfer (CEST) imaging in vitro. Magn Reson Med. 2019;82(3):935-947. doi:10.1002/mrm.27778 [doi]

7. Wang X, Keupp J, Dimitrov IE, et al. Evaluation of renal masses with CEST MRI: Protocol optimization and preliminary results. Magn Reson Med. 2025;94(6):2374-2387. doi:10.1002/mrm.30641 [doi]

8. Wu X, Schmitter S, Auerbach EJ, Uğurbil K, Moortele PFV de. Mitigating transmit B1 inhomogeneity in the liver at 7T using multispoke parallel transmit RF pulse design. Quantitative Imaging in Medicine and Surgery. 2014;4(1):40-10. doi:10.3978/j.issn.2223-4292.2014.02.06 [doi]

9. Bulanov P, Menshchikov P, Grimm JA, et al. Human liver CEST imaging at 7 T: Impact of B 1 + shimming. Magn Reson Med. 2025;94(4):1604-1615. doi:10.1002/mrm.30557 [doi]

10. Lambert PP. Polycystic disease of the kidney; a review. Arch Pathol (Chic). 1947;44(1):34-58.

11. Waingankar N, Hayek S, Smith AD, Okeke Z. Calyceal Diverticula: A Comprehensive Review. Rev Urol. 2014;16(1):29-43.

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http://echo.ismrm.org/p/ISMRM2026/431-02-003