664-02-011 ISMRM Abstract

Design of a stimulator for porcine cardiac stimulation measurements at multiple frequencies

Primary: Physics & Engineering - Safety

Secondary: Physics & Engineering - Bioeffects & Magnetic Fields

664-02-011 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E

Keywords: Computational Electromagnetics Large animal model Cardiac stimulation Gradient safety Magnetic stimulation

Accepted

Valerie Klein ^1,2, Christopher Nguyen³, Zi Xiong², Lawrence L Wald^1,2,4, Bastien Guerin^1,2

¹Harvard Medical School, Boston, United States of America

²Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

³Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States of America, United States of America

⁴Harvard-MIT Health Sciences and Technology, Cambridge, United States of America

Presenting Author: Valerie Klein

Synopsis

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References

1. IEC, International standard IEC 60601 medical electrical equipment. Part 2-33: Particular requirements for the basic safety and essential performance of magnetic resonance equipment for medical diagnosis. 2022, International Electrotechnical Commission (IEC).

2. Reilly J P, Principles of nerve and heart excitation by time-varying magnetic fields. Ann. N. Y. Acad. Sci., 1992. 649: 96-117.

3. Reilly J P, Magnetic field excitation of peripheral nerves and the heart: A comparison of thresholds. Med. Biol. Eng. Comput., 1991. 29: 571-579.

4. Setsompop K, Kimmlingen R, Eberlein E, Witzel T, Cohen-Adad J, McNab J A, Keil B, Tisdall M D, Hoecht P, Dietz P, Caluey S F, Tountcheva V, Matschl V, Lenz V H, Heberlein K, Potthast A, Thein H, Van Horn J, Toga A, Schmitt F, Lehne D, Rosen B R, Wedeen V, and Wald L L, Pushing the limits of in vivo diffusion MRI for the Human Connectome Project. NeuroImage, 2013. 80: 220-233.

5. Klein V, Davids M, Schad L R, Wald L L, and Guérin B, Investigating cardiac stimulation limits of MRI gradient coils using electromagnetic and electrophysiological simulations in human and canine body models. Magn. Reson. Med., 2021. 85: 1047–1061.

6. Klein V, Davids M, Vendramini L, Ferris N G, Schad L R, Sosnovik D E, Nguyen C T, Wald L L, and Guerin B, Prediction of experimental cardiac magnetotimulation thresholds using pig-specific body models. Magn Reson Med, 2023. 90: 1594-1609.

7. Klein V, Coll-Font J, Vendramini L, Straney D, Davids M, Ferris N G, Schad L R, Sosnovik D E, Nguyen C T, Wald L L, and Guérin B, Measurement of magnetostimulation thresholds in the porcine heart. Magn. Reson. Med., 2022. 88: 2242-2258.

8. Stewart P, Aslanidi O V, Noble D, Noble P J, Boyett M R, and Zhang H, Mathematical models of the electrical action potential of Purkinje fibre cells. Phil. Trans. R. Soc. A, 2009. 367: 2225-2255.

9. Rudy Y and Quan W, Propagation delays across cardiac gap junctions and their reflection in extracellular potentials: A simulation study. J. Cardiovasc. Electrophysiol., 1991. 2(4): 299-315.

10. Lapicque L, Definition expérimentale de l’excitabilité. Comptes Rendus Acad. Sci., 1909. 67(2): 208-283.

11. Kamon M, Efficient techniques for inductance extraction of complex 3-D geometries, in Electrical Engineering and Computer Science. 1994, Massachusetts Institute of Technology.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/664-02-011