Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-012 / 331-01-012 ISMRM Abstract

Impaired Pentose Phosphate Pathway Flux in Mouse Model of Depression

Accepted
Anant B Patel1, Pravin K Mishra1, Ajay Sarawagi 1, Hilal Roshan1
1NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India
Presenting Author: Ajay Sarawagi

Synopsis

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References

1. Santomauro, D. F. et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. The Lancet 398, 1700–1712 (2021).
2. Abdallah, C. G. et al. Glutamate Metabolism in Major Depressive Disorder. Am. J. Psychiatry 171, 1320–1327 (2014).
3. Mishra, P. K., Kumar, A., Behar, K. L. & Patel, A. B. Subanesthetic ketamine reverses neuronal and astroglial metabolic activity deficits in a social defeat model of depression. J. Neurochem. 146, 722–734 (2018).
4. TeSlaa, T., Ralser, M., Fan, J. & Rabinowitz, J. D. The pentose phosphate pathway in health and disease. Nat. Metab. 5, 1275–1289 (2023).
5. Puthumana, J. S. & Regenold, W. T. Glucose-6-phosphate dehydrogenase activity in bipolar disorder and schizophrenia: Relationship to mitochondrial impairment. J. Psychiatr. Res. 112, 99–103 (2019).
6. Detka, J. et al. Brain glucose metabolism in an animal model of depression. Neuroscience 295, 198–208 (2015).
7. Golden, S. A., Covington, H. E., Berton, O. & Russo, S. J. A standardized protocol for repeated social defeat stress in mice. Nat. Protoc. 6, 1183–1191 (2011).
8. Veeraiah, P. et al. Dysfunctional Glutamatergic and γ-Aminobutyric Acidergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. Biol. Psychiatry 76, 231–238 (2014).
9. Liu, M.-Y. et al. Sucrose preference test for measurement of stress-induced anhedonia in mice. Nat. Protoc. 13, 1686–1698 (2018).
10. Fitzpatrick, S. M., Hetherington, H. P., Behar, K. L. & Shulman, R. G. The Flux from Glucose to Glutamate in the Rat Brain in vivo as Determined by 1 -Observed, 13 C-Edited NMR Spectroscopy. J. Cereb. Blood Flow Metab. 10, 170–179 (1990).
11. Tiwari, V., Ambadipudi, S. & Patel, A. B. Glutamatergic and GABAergic TCA Cycle and Neurotransmitter Cycling Fluxes in Different Regions of Mouse Brain. J. Cereb. Blood Flow Metab. 33, 1523–1531 (2013).
12. Patel, A. B., Rothman, D. L., Cline, G. W. & Behar, K. L. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Res. 919, 207–220 (2001).
13. Brekke, E. M. et al. The Pentose Phosphate Pathway and Pyruvate Carboxylation after Neonatal Hypoxic-Ischemic Brain Injury. J. Cereb. Blood Flow Metab. 34, 724–734 (2014).
14. Sarawagi, A., Soni, N. D. & Patel, A. B. Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder. Front. Psychiatry 12, 637863 (2021).
15. Tiwari, V. & Patel, A. B. Pyruvate Carboxylase and Pentose Phosphate Fluxes are Reduced in AβPP-PS1 Mouse Model of Alzheimer’s Disease: A 13C NMR Study. J. Alzheimer’s Dis. 41, 387–399 (2014).
16. Lapidus, K. A. B. et al. In vivo 1H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder. Neurosci. Lett. 569, 74–79 (2014).

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