Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-01-009 Registered Abstract

Collaborative Multi-site Preclinical MRS Study (CoMP-MRS) – Preliminary Results

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
462-01-009 · Contrast Mechanisms Potpourri Including Registered/Clinical Abstracts · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row C
Keywords: Brain Preclinical MRS Spectral quality Multi-center
Accepted
Diana G. Rotaru 1,2, Mark Mikkelsen3, Georg Oeltzschner4, Thanh Phong Lê5,6, Colleen Bailey7, Emma Van Praagh1,8, Eloise Mougel5,6, Joanes Grandjean9,10, Jamie Near7,11,12,13,14, Cristina Cudalbu5,6, the CoMP-MRS consortium
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
2Columbia University, New York, United States of America
3Weill Cornell Medicine, New York, United States of America
4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
5CIBM Pre-Clinical Imaging EPFL Metabolic Imaging Section, École Polytechnique Fédérale de Lausanne - EPFL, Lausanne, Switzerland
6CIBM Center for Biomedical Imaging, Lausanne, Switzerland
7Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada
8Department of Biomedical Engineering, Columbia University, New York, United States of America
9Department for Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands
10Donders Institute for Brain, Behaviour, and Cognition, Radboud University, Nijmegen, Netherlands
11Department of Medical Biophysics, University of Toronto, Toronto, Canada
12Centre d'Imagerie Cérébrale, Douglas Institute, Montreal, Canada
13Integrated Program in Neurosciences, McGill University, Montreal, Canada
14Department of Biomedical Engineering, McGill University, Montreal, Canada
Presenting Author: Diana G. Rotaru

Synopsis

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References

1. CoMP-MRS_studyProtocol. In: Google Docs [Internet]. [cited 16 Oct 2025]. Available: https://docs.google.com/document/d/1mkTT8u335IsdfgcMNpL1zkaJSX638t4izRNTcMOhe_4/edit?usp=sharing
2. Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, et al. A consensus protocol for functional connectivity analysis in the rat brain. Nat Neurosci. 2023;26: 673–681. doi:10.1038/s41593-023-01286-8 [doi]
3. Bouchard AE, Wong D, Bogner W, Gau R, Halchenko YO, Lamb DG, et al. MRS-BIDS, an extension to the Brain Imaging Data Structure for magnetic resonance spectroscopy. Sci Data. 2025;12: 1384. doi:10.1038/s41597-025-05543-2 [doi]
4. CoMP-MRS_participantSpreadsheet. In: Google Docs [Internet]. [cited 16 Oct 2025]. Available: https://docs.google.com/spreadsheets/d/1z6yxFSnsiuZsXPj_JkK8_Qh8ZtAfPP7kzJs9b7p25BI/edit?gid=1410829108
5. Simpson R, Devenyi GA, Jezzard P, Hennessy TJ, Near J. Advanced processing and simulation of MRS data using the FID appliance (FID-A)-An open source, MATLAB-based toolkit. Magn Reson Med. 2017;77: 23–33. doi:10.1002/mrm.26091 [doi]
6. Snijders T, Bosker R. Multilevel analysis : an introduction to basic and advanced multilevel modeling. 1999. Available: https://www.researchgate.net/publication/44827177
7. Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models Usinglme4. J Stat Softw. 2015;67. doi:10.18637/jss.v067.i01 [doi]
8. Mikkelsen M, Barker PB, Bhattacharyya PK, Brix MK, Buur PF, Cecil KM, et al. Big GABA: Edited MR spectroscopy at 24 research sites. Neuroimage. 2017;159: 32–45. doi:10.1016/j.neuroimage.2017.07.021 [doi]

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http://echo.ismrm.org/p/ISMRM2026/462-01-009