Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
531-02-011 / 531-02-011 ISMRM Abstract

Tract-Specific White Matter Microstructure Predicts Deep Brain Stimulation Response in Parkinson’s Disease

Accepted
Devin Schoen 1,2, Philip Shih1, Skyler Deutsch1, Juhi Mehta1, Sarah S Wang3, John Kornak4, Ian O Bledsoe3, Jill L Ostrem3, Melanie A Morrison1,2
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, United States of America
2Graduate Group in Bioengineering, University of California, Berkeley, United States of America
3Department of Neurology, University of California San Francisco, San Francisco, United States of America
4Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, United States of America
Presenting Author: Devin Schoen

Synopsis

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References

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2. Fenoy, A. J., & Schiess, M. C. (2017). Deep Brain Stimulation of the Dentato-Rubro-Thalamic Tract: Outcomes of Direct Targeting for Tremor. Neuromodulation: Technology at the Neural Interface, 20(5), 429–436. https://doi.org/10.1111/ner.12585 [doi]
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6. Loehrer, P. A., Freigang, J., Bopp, M. H. A., Calvano, A., Dafsari, H. S., Wichmann, J., Seidel, A., Aberle, C., Knake, S., Nimsky, C., Timmermann, L., Belke, M., & Pedrosa, D. J. (2025). Microstructure is associated with motor outcomes following Deep Brain Stimulation in Parkinson’s disease. Npj Parkinson’s Disease, 11(1), 81. https://doi.org/10.1038/s41531-025-00930-3 [doi]
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10. Schoen, D., Deutsch, S., Mehta, J., Wang, S., Kornak, J., Starr, P. A., Wang, D. D., Ostrem, J. L., Bledsoe, I. O., & Morrison, M. A. (2025). Boundary complexity of cortical and subcortical areas predicts deep brain stimulation outcomes in Parkinson’s disease. Nature Communications, 16(1), 5590. https://doi.org/10.1038/s41467-025-60695-4 [doi]
11. Yang, A. I., Parker, D., Vijayakumari, A. A., Ramayya, A. G., Donley-Fletcher, M. P., Aunapu, D., Wolf, R. L., Baltuch, G. H., & Verma, R. (2022). Tractography-Based Surgical Targeting for Thalamic Deep Brain Stimulation: A Comparison of Probabilistic vs Deterministic Fiber Tracking of the Dentato-Rubro-Thalamic Tract. Neurosurgery, 90(4), 419–425. https://doi.org/10.1227/NEU.0000000000001840 [doi]
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