Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-04-005 ISMRM Abstract

Small vessel morphology affects the temporal sequence of white matter free water and DTI-ALPS in CADASIL

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - Blood Vessels
663-04-005 · Cerebral Small Vessel Disease: Network, Glymphatic, and Blood Flow · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Glymphatic system Free water DTI-ALPS Diffusion Tensor Imaging (DTI)
Accepted
Xuejia Jia1, Jiajia Zhang 1, Yingying Li1, Chen Zhang2, Xiuqin Jia1, Qi Yang1
1Department of Radiology, Beijing Chao-Yang Hospital, Beijing, China
2MR Research Collaboration, Siemens Healthineers, Beijing China, China
Presenting Author: Jiajia Zhang

Synopsis

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References

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2. Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4(147):147ra111. doi:10.1126/scitranslmed.3003748 [doi]
3. Bakker ENTP, Bacskai BJ, Arbel-Ornath M, et al. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell Mol Neurobiol. 2016;36(2):181-194. doi:10.1007/s10571-015-0273-8 [doi]
4. Drenthen GS, Elschot EP, van der Knaap N, et al. Imaging Interstitial Fluid With MRI: A Narrative Review on the Associations of Altered Interstitial Fluid With Vascular and Neurodegenerative Abnormalities. J Magn Reson Imaging. 2024;60(1):40-53. doi:10.1002/jmri.29056 [doi]
5. Liu X, Barisano G, Shao X, et al. Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function. Aging Dis. 2024;15(4):1885-1898. doi:10.14336/AD.2023.0321-2 [doi]
6. Duering M, Finsterwalder S, Baykara E, et al. Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Alzheimers Dement J Alzheimers Assoc. 2018;14(6):764-774. doi:10.1016/j.jalz.2017.12.007 [doi]
7. Zhang W, Zhou Y, Wang J, et al. Glymphatic clearance function in patients with cerebral small vessel disease. NeuroImage. 2021;238:118257. doi:10.1016/j.neuroimage.2021.118257 [doi]
8. Taoka T, Masutani Y, Kawai H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol. 2017;35(4):172-178. doi:10.1007/s11604-017-0617-z [doi]
9. Hong H, Tozer DJ, Markus HS. Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease. Stroke. 2024;55(4):1032-1040. doi:10.1161/STROKEAHA.123.045857 [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-04-005