Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-03-006 / 331-03-006 ISMRM Abstract

Mapping striatal functional gradients and their associations with clinical symptoms in obsessive-compulsive disorder

Primary: Neuro - Psychiatric Disorders
Secondary: Brain Function and fMRI - Functional Connectivity
331-03-006 · Clinical Applications in Psychiatry and Neurology · Monday, 11 May, 4:10 PM–5:36 PM · Roof Terrace
331-03-006 · Clinical Applications in Psychiatry and Neurology · Monday, 11 May, 4:10 PM–5:36 PM · Roof Terrace
Keywords: Psychiatric Disorders Subcortical structure Anxiety Functional magnetic resonance imaging Functional connectivity gradient
Accepted
Lingxiao Cao 1, Hailong Li1, Shuangwei Chai1, Sarah Genon2, Bin Li3, Xiaoqi Huang1
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, China
2Institute of Neuroscience and Medicine, Brain and Behaviour (INM‑7), Research Center Jülich, Jülich, Germany
3Mental Health Center, West China Hospital, Sichuan University, Chengdu, China
Presenting Author: Lingxiao Cao

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References

1. Stein DJ, Costa DLC, Lochner C, et al. Obsessive-compulsive disorder. Nat Rev Dis Primers. 2019;5(1):52. Published 2019 Aug 1. doi:10.1038/s41572-019-0102-3 [doi]
2. Oldehinkel M, Tiego J, Sabaroedin K, et al. Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy. Transl Psychiatry. 2023;13(1):128. Published 2023 Apr 18. doi:10.1038/s41398-023-02417-2 [doi]
3. Li X, Bu S, Pang H, et al. Mapping striatal functional gradients and associated gene expression in Parkinson's disease with continuous cognitive impairment. NPJ Parkinsons Dis. 2025;11(1):138. Published 2025 May 28. doi:10.1038/s41531-025-01002-2 [doi]
4. Marquand AF, Haak KV, Beckmann CF. Functional corticostriatal connection topographies predict goal directed behaviour in humans. Nat Hum Behav. 2017;1(8):0146. doi:10.1038/s41562-017-0146 [doi]
5. Oldehinkel M, Llera A, Faber M, et al. Mapping dopaminergic projections in the human brain with resting-state fMRI. Elife. 2022;11:e71846. Published 2022 Feb 3. doi:10.7554/eLife.71846 [doi]
6. Seiler JL, Cosme CV, Sherathiya VN, et al. Dopamine signaling in the dorsomedial striatum promotes compulsive behavior. Curr Biol. 2022;32(5):1175-1188.e5. doi:10.1016/j.cub.2022.01.055 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-03-006