404-02-001 / 271-01-027 ISMRM Abstract

Neurochemical Indicators of Cognitive Performance assessed by 7T MR Spectroscopy in the Aging Adult Brain Connectome Cohort

Primary: Contrast Mechanisms - Spectroscopy

Secondary: Neuro - Aging

404-02-001 · Altered Metabolism Across Healthy Aging and Neurological Disorders · Tuesday, 12 May, 8:20 AM–10:10 AM · Ballroom East

271-01-027 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters

Keywords: Neuro Cognition 7 Tesla Ageing Magnetic Resonance Spectroscopy

Accepted

Eva-Maria Ratai ¹, Malgorzata Marjanska², Yue Hong¹, Yiwen Zhang¹, Melissa Terpstra², Guglielmo Genovese^2,3, Jeromy Thotland², Michael Wolf², Meher R Juttukonda¹, Jan A Kufer¹, Christa Michel^4,5, Courtney Accorsi¹, Adam Khay¹, Essa Yacoub², Petra Lenzini⁶, Lauren Antonucci¹, Gayathri Vijayaraghavan¹, Steven Arnold⁷, Robert C Welsh⁸, Jennifer Elam⁶, Dara Ghahremani,⁸, Carlos Cruchaga⁶, Matthew Glasser⁶, Michael Harms⁶, Pauline Maki⁹, Susan Bookheimer⁸, Helen Lavretsky⁸, Thomas Nichols¹⁰, Beau Ances⁶, David H Salat¹

¹Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

²Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, United States of America

³Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology NTNU, Norway

⁴Carnegie Mellon University, Pittsburgh, United States of America

⁵Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

⁶Washington University in St. Louis, St. Louis, United States of America

⁷Massachusetts General Hospital, Boston, United States of America

⁸UCLA Health, Los Angeles, United States of America

⁹University of Illinois Chicago, Chicago, United States of America

¹⁰Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, Oxford, United Kingdom

Presenting Author: Eva-Maria Ratai

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References

1. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 2001 Jun;14(4):260-4. PMID: 11410943 [pmid]

2. Marjańska M, McCarten JR, Hodges J, Hemmy LS, Grant A, Deelchand DK, Terpstra M. Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1H magnetic resonance spectroscopy at 7 T. Neuroscience. 2017 Jun 23;354:168-177. PMID: 28476320 [pmid]

3. Bookheimer, S. Y. et al. The Lifespan Human Connectome Project in Aging: An overview. Neuroimage 185, 335–348 (2019). PMID: 30332613 [pmid]

4. Harms, M. P. et al. Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects. Neuroimage 183, 972–984 (2018). PMID: 30261308 [pmid]

5. Weintraub, S. et al. Cognition assessment using the NIH Toolbox. Neurology 80, S54–S64 (2013). PMID: 23479546 [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/404-02-001