Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-04-008 ISMRM Abstract

Longitudinal trajectories of structural neurodevelopmental outcomes in young children who are HIV-exposed uninfected

Primary: Neuro - Neuroinflammation
Secondary: Pediatrics - Neuro
566-04-008 · Predicting Neurologic Outcomes · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row G
Keywords: HIV exposure Structural MRI Trajectory Modeling Structural Neurodevelopment In utero development
Accepted
Simone R Williams 1,2, Hayli Geffen2, Zayaan Goolam Nabi1, Michal M Zieff1, Jessica E Ringshaw1,3, Lauren Davel1, Candice Knipe1, Bokang Methola1, Rabelani Negota1, Khanyisa Nkubungu1, Layla Bradford1, Anele Khumalo1, Thandeka Mazubane1, Nwabisa Mlandu1, Zamazimba Madi1, Tembeka Mhlakwaphalwa1, Reese Samuels1, Donna Herr1, Marlie Miles1, Niall J Bourke, Daniel C Alexander4, Derek K Jones5, Steven Williams3, Catherine Wedderburn1, Kirsten A Donald1
1Division of Developmental Paediatrics, Department of Paediatrics and Child Health and Neuroscience Institute, University of Cape Town, South Africa, South Africa
2Division of Epidemiology & Biostatistics, School of Public Health, University of Cape Town, South Africa
3Centre for Neuroimaging Sciences, King's College London, London, United Kingdom
4Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom
5Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
Presenting Author: Simone R Williams

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References

1. 1 Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M. & Sestan, N. The Cellular and Molecular Landscapes of the Developing Human Central Nervous System. Neuron 89, 248-268 (2016). https://doi.org/10.1016/j.neuron.2015.12.008 [doi]
2. 2 Wedderburn, C. J. et al. Early neurodevelopment of HIV-exposed uninfected children in the era of antiretroviral therapy: a systematic review and meta-analysis. Lancet Child Adolesc Health 6, 393-408 (2022). https://doi.org/10.1016/s2352-4642(22)00071-2 [doi]
3. 3 McHenry, M. S. et al. Neurodevelopment in Young Children Born to HIV-Infected Mothers: A Meta-analysis. Pediatrics 141 (2018). https://doi.org/10.1542/peds.2017-2888 [doi]
4. 4 Wedderburn, C. J. et al. Subcortical Brain Volumes and Neurocognitive Function in Children With Perinatal HIV Exposure: A Population-Based Cohort Study in South Africa. Open Forum Infectious Diseases 11 (2024). https://doi.org/10.1093/ofid/ofae317 [doi]
5. 5 Wedderburn, C. J. et al. Early structural brain development in infants exposed to HIV and antiretroviral therapy in utero in a South African birth cohort. J Int AIDS Soc 25, e25863 (2022). https://doi.org/10.1002/jia2.25863 [doi]
6. 6 Magondo, N. et al. Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected. bioRxiv (2024). https://doi.org/10.1101/2024.01.11.575169 [doi]
7. 7 Yadav, S. K. et al. Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers. Brain, Behavior, & Immunity - Health 2, 100039 (2020). https://doi.org/https://doi.org/10.1016/j.bbih.2020.100039 [doi]
8. 8 Fischl, B. FreeSurfer. NeuroImage 62, 774-781 (2012). https://doi.org/10.1016/j.neuroimage.2012.01.021 [doi]
9. 9 Billot, B. et al. SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining. Medical Image Analysis 86, 102789 (2023). https://doi.org/https://doi.org/10.1016/j.media.2023.102789 [doi]
10. 10.        Zieff MR, Miles M, Mbale E et al. Characterizing developing executive functions in the first 1000 days in South Africa and Malawi: The Khula Study [version 1; peer review: 2 approved with reservations]. Wellcome Open Res 2024, 9:157 (https://doi.org/10.12688/wellcomeopenres.19638.1) [doi]

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http://echo.ismrm.org/p/ISMRM2026/566-04-008