Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-001 ISMRM Abstract

MRI-Based Perivascular Space Network Disturbance and Enhanced Coupling in Parkinson’s Disease

Primary: Neuro - Parkinson's Disease
Secondary: Neuro - Neurofluids
460-05-001 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: Parkinson's Disease Diffusion MRI Cognitive impairment Glymphatic system (GS) Perivascular spaces (PVS)
Accepted
Yang Zhao1, Yufan Chen1, Tao Gong1,2, Xiuzheng Yue 3,4,5, guangbin wang1
1Department of Radiograpy, Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
2Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250022, China
3Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
4Medical Big Data Research Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
5Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China
Presenting Author: Xiuzheng Yue

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References

1. Xing Y, Lin M, Li J, et al. Perivascular space fluid diffusivity predicts clinical deterioration in prodromal and early-stage Parkinson’s disease. Npj Park Dis. 2025;11(1):169. doi:10.1038/s41531-025-01036-6 [doi]
2. Ayral V, Pastor-Bernier A, Daneault V, et al. Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study. Neurology. 2025;105(7):e214042. doi:10.1212/WNL.0000000000214042 [doi]
3. Qin J, Fang Y, Duanmu X, et al. The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson’s disease. Npj Park Dis. 2025;11(1):288. doi:10.1038/s41531-025-01139-0 [doi]
4. Passaretti M, Veréb D, Mijalkov M, et al. Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease. Mol Neurodegener. 2025;20(1):74. doi:10.1186/s13024-025-00866-5 [doi]
5. Li Z, Miao X, Zhang Q, et al. Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease. Npj Park Dis. 2025;11(1):218. doi:10.1038/s41531-025-01074-0 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-05-001