Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
631-02-011 / 631-02-011 ISMRM Abstract

Zero Is Not a Magic Number: Bias from Excluding Negative Ktrans in Hippocampal DCE-MRI

Primary: Contrast Mechanisms - Perfusion
Secondary: Analysis Methods - Data Processing
631-02-011 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace
631-02-011 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace
Keywords: Hippocampus DCE-MRI Blood-brain barrier APOE4
Accepted
Irene K Mikkelsen 1, Malene Kaasing1, Ryan Sangill1, Dora Grauballe1, Lasse S Madsen1, Louisa Erichsen1, Pernille L Kjeldsen1,2, David J Brooks1,2,3, Simon F Eskildsen1, Leif Østergaard1,4
1Center of functionally integrative neuroscience, Department of clinical medicine, Aarhus University, Aarhus, Denmark
2Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus N, Denmark
3Newcastle Magnetic Resonance Centre, Translational and Clinical Research Institue, Newcastle University, Newcastle upon Tyne, United Kingdom
4Aarhus University Hospital, Aarhus N, Denmark
Presenting Author: Irene K Mikkelsen

Synopsis

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References

1. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 May;581(7806):71-76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29. PMID: 32376954; PMCID: PMC7250000. [doi] [pmid]
2. Montagne A, Barnes SR, Nation DA, Kisler K, Toga AW, Zlokovic BV. Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions. Geroscience. 2022 Jun;44(3):1339-1351. doi: 10.1007/s11357-022-00571-x. Epub 2022 Apr 25. PMID: 35469116; PMCID: PMC9213625. [doi] [pmid]
3. Thrippleton MJ, Backes WH, Sourbron S, Ingrisch M, van Osch MJP, Dichgans M, Fazekas F, Ropele S, Frayne R, van Oostenbrugge RJ, Smith EE, Wardlaw JM. Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Alzheimers Dement. 2019 Jun;15(6):840-858. doi: 10.1016/j.jalz.2019.01.013. Epub 2019 Apr 25. PMID: 31031101; PMCID: PMC6565805. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/631-02-011