331-01-004 / 331-01-004 ISMRM Abstract

Exploring myelin integrity in a mouse model of Huntington's Disease using Inhomogeneous Magnetization Transfer

Primary: Preclinical Animal & in vitro MR - Small Animals

Secondary: Neuro - Other Neurodegeneration

331-01-004 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace

Keywords: Neuroscience Neurodegeneration Biomarker Preclinical Imaging

Accepted

Andrea Estevez Velez^1,2, Joëlle van Rijswijk^1,2, Johan Van Audekerke^1,3, Ignace Van Spilbeeck^1,3, Mohit H Adhikari^1,2, Roger Cachope⁴, Dorian Pustina⁴, Marleen Verhoye ^1,2, Daniele Bertoglio^1,2

¹Bio Imaging Lab, University of Antwerp, Antwerp, Belgium

²μNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium

³µNEURO Center for Excellence, University of Antwerp, Antwerp, Belgium

⁴CHDI Management, United States of America

Presenting Author: Marleen Verhoye

Synopsis

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References

1. Bates, G.P., et al., Huntington disease. Nature Reviews Disease Primers, 2015. 1(1): p. 15005. 10.1038/nrdp.2015.5 [doi]

2. Vidas-Guscic N, et al. Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington’s disease. Neurobiol Dis. 2024 Apr 1. 10.1016/j.nbd.2024.106438. [doi]

3. Winkler AM, et al. Permutation inference for the general linear model. NeuroImage. 2014 May 15;92:381–97. 10.1016/j.neuroimage.2014.01.060. [doi]

4. Hertanu, A., et al., Inhomogeneous Magnetization Transfer (ihMT) imaging in the acute cuprizone mouse model of demyelination/remyelination. Neuroimage, 2023. 265 : p.119785. 10.1016/j.neuroimage.2022.119785 [doi]

5. Hertanu A, et al., T1D -weighted ihMT imaging - Part I. Isolation of long- and short-T1D components by T1D -filtering. Magn Reson Med. 2022 May;87(5):2313-2328. doi: 10.1002/mrm.29139. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-01-004