Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
569-04-004 ISMRM Abstract

First implementation of preclinical ¹H-FID-MRSI with Concentric Ring Trajectory for rodent brain metabolic mapping at 9.4T

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Preclinical Animal & in vitro MR - Small Animals
569-04-004 · Spectroscopy: Acquisition and Reconstruction · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row J
Keywords: Brain Preclinical MRSI Sequence development Rat
Accepted
Thanh Phong Lê 1,2, Brayan Alves1,2, Bernhard Strasser3, Wolfgang Bogner3,4,5, Tan Toi Phan1,2, Bernard Lanz1,2, Cristina Cudalbu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland
2CIBM Pre-Clinical Imaging EPFL Metabolic Imaging Section, École polytechnique fédérale de Lausanne - EPFL, Lausanne, Switzerland
3High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
4Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Medical University of Vienna, Vienna, Austria
5Comprehensive Center for Artificial Intelligence in Medicine (CAIM), Medical University of Vienna, Vienna, Austria
Presenting Author: Thanh Phong Lê

Synopsis

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References

1. Lipka A, Bogner W, Dal-Bianco A, et al. Metabolic Insights into Iron Deposition in Relapsing-Remitting Multiple Sclerosis via 7 T Magnetic Resonance Spectroscopic Imaging. NeuroImage Clin. 2023;40:103524. doi:10.1016/j.nicl.2023.103524 [doi]
2. Heckova E, Dal-Bianco A, Strasser B, et al. Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis. Radiology. 2022;303(1):141-150. doi:10.1148/radiol.210614 [doi]
3. Delgado-Goñi T, Ortega-Martorell S, Ciezka M, et al. MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis. NMR Biomed. 2016;29(6):732-743. doi:10.1002/nbm.3521 [doi]
4. Simicic D, Alves B, Mosso J, et al. Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T. NMR Biomed. 2025;38(2):e5304. doi:10.1002/nbm.5304 [doi]
5. Alves B, Simicic D, Mosso J, et al. Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application. NMR Biomed. Published online July 23, 2024:e5211. doi:10.1002/nbm.5211 [doi]
6. Bogner W, Otazo R, Henning A. Accelerated MR spectroscopic imaging—a review of current and emerging techniques. NMR Biomed. 2021;34(5). doi:10.1002/nbm.4314 [doi]
7. Chambers S, Lazen P, Hotka M, et al. Glutamine Metabolism and Metabolic Profiling Using 7 T CRT-FID MRSI in Focal Epilepsy. Eur J Neurol. 2025;32(9):e70343. doi:10.1111/ene.70343 [doi]
8. Nam KM, Hendriks AD, Boer VO, Klomp DWJ, Wijnen JP, Bhogal AA. Proton metabolic mapping of the brain at 7 T using a two-dimensional free induction decay–echo-planar spectroscopic imaging readout with lipid suppression. NMR Biomed. 2022;35(10):e4771. doi:10.1002/nbm.4771 [doi]
9. Hnilicová P, Považan M, Strasser B, et al. Spatial variability and reproducibility of GABA-edited MEGA-LASER 3D-MRSI in the brain at 3 T. NMR Biomed. 2016;29(11):1656-1665. doi:10.1002/nbm.3613 [doi]
10. Hiba B, Faure B, Lamalle L, Décorps M, Ziegler A. Out-and-in spiral spectroscopic imaging in rat brain at 7 T. Magn Reson Med. 2003;50(6):1127-1133. doi:10.1002/mrm.10622 [doi]
11. Hangel G, Niess E, Lazen P, Bednarik P, Bogner W, Strasser B. Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain. Anal Biochem. 2022;638:114479. doi:10.1016/j.ab.2021.114479 [doi]
12. Hingerl L, Strasser B, Moser P, et al. Clinical High-Resolution 3D-MR Spectroscopic Imaging of the Human Brain at 7 T. Invest Radiol. 2020;55(4):239-248. doi:10.1097/RLI.0000000000000626 [doi]
13. Jiang W, Lustig M, Larson PEZ. Concentric rings K-space trajectory for hyperpolarized 13C MR spectroscopic imaging. Magn Reson Med. 2016;75:19-31. doi:10.1002/mrm.25577 [doi]
14. Niess F, Strasser B, Hingerl L, et al. Whole-brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism. Hum Brain Mapp. 2024;45(6):e26686. doi:10.1002/hbm.26686 [doi]
15. Clarke WT, Hingerl L, Strasser B, Bogner W, Valkovič L, Rodgers CT. Three-dimensional, 2.5-minute, 7T phosphorus magnetic resonance spectroscopic imaging of the human heart using concentric rings. NMR Biomed. 2023;36(1):e4813. doi:10.1002/nbm.4813 [doi]
16. AlvBrayan. AlvBrayan/MRS4Brain-toolbox. https://github.com/AlvBrayan/MRS4Brain-toolbox
17. Starčuk Z, Starčuková J. Quantum-mechanical simulations for in vivo MR spectroscopy: Principles and possibilities demonstrated with the program NMRScopeB. Anal Biochem. 2017;529:79-97. doi:10.1016/j.ab.2016.10.007 [doi]
18. Govind V, Young K, Maudsley AA. Corrigendum to Proton NMR chemical shifts and coupling constants for brain metabolites. [NMR Biomed. 13, (2000), 129-153]. NMR Biomed. 2015;28(7):923-924. doi:10.1002/nbm.3336 [doi]
19. Govindaraju V MA Young K. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000;13:129-153. doi:10.1002/1099-1492(200005)13:33.3.CO;2-M [doi]

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http://echo.ismrm.org/p/ISMRM2026/569-04-004