401-04-004 ISMRM Abstract

Hyperpolarized 13C Pyruvate MRI: Quantifying Glycolytic Hypermetabolism for Viability Assessment Post-Myocardial Infarction

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Cardiovascular - Myocardium

401-04-004 · Metabolism · Tuesday, 12 May, 4:00 PM–5:50 PM · Hall 1A

Keywords: Ischemia Metabolism 1-13C Pyruvate Cardiovascular magnetic resonance

Accepted

Esben S Hansen ¹, Nikolaj Bøgh¹, Jakob Lindhardt¹, Rasmus S Tougaard², Won Y Kim², Christoffer Laustsen¹

¹MR Research Centre, Aarhus University, Aarhus, Denmark

²Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark

Presenting Author: Esben S Hansen

Synopsis

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References

1. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. D. J. Hausenloy and D. M. Yellon. DOI: 10.1172/jci62874 [doi]

2. Veno-occlusive unloading of the heart reduces infarct size in experimental ischemia–reperfusion. E. S. S. Hansen, T. L. Madsen, G. Wood, A. Granfeldt, N. Bøgh, B. J. Tofig, et al. DOI: 10.1038/s41598-021-84025-y [doi]

3. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. J. H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M. H. Lerche, et al. DOI: 10.1073/pnas.1733835100 [doi]

4. Saturation-recovery metabolic-exchange rate imaging with hyperpolarized [1-13C] pyruvate using spectral-spatial excitation. R. F. Schulte, J. I. Sperl, E. Weidl, M. I. Menzel, M. A. Janich, O. Khegai, et al. DOI: https://doi.org/10.1002/mrm.24353 [doi]

5. Noninvasive Immunometabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic Resonance. A. J. M. Lewis, J. J. Miller, A. Z. Lau, M. K. Curtis, O. J. Rider, R. P. Choudhury, et al. DOI: 10.1161/circresaha.117.312535 [doi]

6. Current methods for hyperpolarized [1-(13)C]pyruvate MRI human studies. P. E. Z. Larson, J. M. L. Bernard, J. A. Bankson, N. Bøgh, R. A. Bok, A. P. Chen, et al. DOI: 10.1002/mrm.29875 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/401-04-004