603-01-001 ISMRM Abstract

Composite Measures Combining Multimodal MRI, Plasma Biomarkers & Cardiovascular Risk are Sensitive to Cognition and Dementia

Primary: Neuro - Aging

Secondary: Neuro - Dementia

603-01-001 · Dementia Not Related to Alzheimer's Disease · Thursday, 14 May, 8:30 AM–10:20 AM · Auditorium 1

Keywords: Glymphatics Aging Alzheimer's Disease Neurovascular Cognition

Accepted

Ella Rowsthorn ^1,2, Ying Xia³, Michael Breakspear^4,5, Jurgen Fripp³, Gail A Robinson^4,6, Michelle K Lupton⁴, Meng Law^1,7,8, Matthew P Pase², Ian H Harding^1,4

¹Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia

²School of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia

³CSIRO Health and Biosecurity, Brisbane, Australia

⁴QIMR Berghofer Medical Research Institute, Brisbane, Australia, Australia

⁵University of Newcastle, Newcastle, Australia

⁶The University of Queensland, Brisbane, Australia

⁷Alfred Health, Melbourne, Australia

⁸Monash University, Melbourne, Australia

Presenting Author: Ella Rowsthorn

Synopsis

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References

1. Rowsthorn E, Cribb L, Sinclair B, Pham W, Chong TT-J, Yiallourou S, Cavuoto M, Vivash L, O’Brien TJ, Shao X, Wang DJJ, Law M, Pase MP, Harding IH. Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study. Fluids Barriers CNS 2025; 22: 59. doi:10.1186/s12987-025-00664-7 [doi]

2. Lupton MK, Robinson GA, Adam RJ, Rose S, Byrne GJ, Salvado O, Pachana NA, Almeida OP, McAloney K, Gordon SD, Raniga P, Fazlollahi A, Xia Y, Ceslis A, Sonkusare S, Zhang Q, Kholghi M, Karunanithi M, Mosley PE, Lv J, Borne L, Adsett J, Garden N, Fripp J, Martin NG, Guo CC, Breakspear M. A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA). NeuroImage Clin 2021; 29: 102527. doi:10.1016/j.nicl.2020.102527 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/603-01-001