Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-06-012 ISMRM Abstract

Quantitative MRI of avascular necrosis: comparison between a piglet model and children with Legg-Calvé-Perthes disease

Primary: Musculoskeletal - Bone
Secondary: Pediatrics - MSK
566-06-012 · Quantitative Outcome Measures in MSK MRI · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row G
Keywords: Ischemia Pediatric Bone Quantitative techniques Large animal model
Accepted
Casey P Johnson , Erick O Buko1,2, Ashton A Amann1,2, Nicole R Nelson1, Suhail Parvaze Pathan1,2, Alexandra R Armstrong1, Susan A Novotny3,4, Jennifer C Laine3,5, Ferenc Tóth1
1Department of Veterinary Clinical Sciences, University of Minnesota, Minneapolis, United States of America
2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States of America
3Gillette Children's Specialty Healthcare, Saint Paul, United States of America
4Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, United States of America
5Department of Orthopedic Surgery, University of Minnesota, Minneapolis, United States of America
Presenting Author: Casey P Johnson

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Kim HK. Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease. J Bone Joint Surg Am. 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623. [doi] [pmid]
2. Laine JC, Martin BD, Novotny SA, Kelly DM. Role of Advanced Imaging in the Diagnosis and Management of Active Legg-Calvé-Perthes Disease. J Am Acad Orthop Surg. 2018 Aug 1;26(15):526-536. doi: 10.5435/JAAOS-D-16-00856. PMID: 29939867. [doi] [pmid]
3. Johnson CP, Wang L, Tóth F, Aruwajoye O, Carlson CS, Kim HKW, Ellermann JM. Quantitative MRI Helps to Detect Hip Ischemia: Preclinical Model of Legg-Calvé-Perthes Disease. Radiology. 2018 Nov;289(2):386-395. doi: 10.1148/radiol.2018180497. PMID: 30063188. [doi] [pmid]
4. Johnson CP, Tóth F, Carlson CS, Armstrong AR, Zbýň Š, Wu B, Ellermann JM, Kim HKW. T1ρ and T2 mapping detect acute ischemic injury in a piglet model of Legg-Calvé-Perthes disease. J Orthop Res. 2022 Feb;40(2):484-494. doi: 10.1002/jor.25044. PMID: 33788301. [doi] [pmid]
5. Armstrong AR, Bhave S, Buko EO, Chase KL, Tóth F, Carlson CS, Ellermann JM, Kim HKW, Johnson CP. Quantitative T2 and T1ρ mapping are sensitive to ischemic injury to the epiphyseal cartilage in an in vivo piglet model of Legg-Calvé-Perthes disease. Osteoarthritis Cartilage. 2022 Sep;30(9):1244-1253. doi: 10.1016/j.joca.2022.05.009. PMID: 35644462. [doi] [pmid]
6. Buko EO, Armstrong AR, Laine JC, Tóth F, Johnson CP. Detection of early metaphyseal changes in a piglet model of Legg-Calvé-Perthes disease using quantitative mapping of MRI relaxation times. J Orthop Res. 2024 Oct;42(10):2277-2286. doi: 10.1002/jor.25904. PMID: 38796746. [doi] [pmid]
7. Buko EO, Bhave S, Moeller S, Laine JC, Tóth F, Johnson CP. Intravoxel incoherent motion (IVIM) detects femoral head ischemia in a piglet model of Legg-Calvé-Perthes disease. J Orthop Res. 2024 Apr;42(4):855-863. doi: 10.1002/jor.25733. PMID: 37971281. [doi] [pmid]
8. Menezes NM, Connolly SA, Shapiro F, Olear EA, Jimenez RM, Zurakowski D, Jaramillo D. Early ischemia in growing piglet skeleton: MR diffusion and perfusion imaging. Radiology. 2007 Jan;242(1):129-36. doi: 10.1148/radiol.2421050680. PMID: 17185664. [doi] [pmid]
9. Yoo WJ, Kim YJ, Menezes NM, Cheon JE, Jaramillo D. Diffusion-weighted MRI reveals epiphyseal and metaphyseal abnormalities in Legg-Calvé-Perthes disease: a pilot study. Clin Orthop Relat Res. 2011 Oct;469(10):2881-8. doi: 10.1007/s11999-011-1931-x. PMID: 21660596. [doi] [pmid]
10. Kim HK, Su PH, Qiu YS. Histopathologic changes in growth-plate cartilage following ischemic necrosis of the capital femoral epiphysis. An experimental investigation in immature pigs. J Bone Joint Surg Am. 2001 May;83(5):688-97. doi: 10.2106/00004623-200105000-00007. PMID: 11379738. [doi] [pmid]
11. Kim HK, Su PH. Development of flattening and apparent fragmentation following ischemic necrosis of the capital femoral epiphysis in a piglet model. J Bone Joint Surg Am. 2002 Aug;84(8):1329-34. doi: 10.2106/00004623-200208000-00006. PMID: 12177261. [doi] [pmid]
12. Hyman JE, Trupia EP, Wright ML, Matsumoto H, Jo CH, Mulpuri K, Joseph B, Kim HK; International Perthes Study Group Members. Interobserver and intraobserver reliability of the modified Waldenström classification system for staging of Legg-Calvé-Perthes disease. J Bone Joint Surg Am. 2015 Apr 15;97(8):643-50. doi: 10.2106/JBJS.N.00887. PMID: 25878308. [doi] [pmid]
13. Buko EO, Parvaze SP, Johnson CP. Optimized analytical segmented method for improved intravoxel incoherent motion parameter extraction in low-perfused tissues. Magn Reson Med. 2025 Dec;94(6):2508-2518. doi: 10.1002/mrm.30636. PMID: 40674616. [doi] [pmid]
14. Veraart J, Fieremans E, Novikov DS. Diffusion MRI noise mapping using random matrix theory. Magn Reson Med. 2016 Nov;76(5):1582-1593. doi: 10.1002/mrm.26059. PMID: 26599599. [doi] [pmid]
15. Moeller S, Buko EO, Parvaze SP, Dowdle L, Ugurbil K, Johnson CP, Akcakaya M. Locally low-rank denoising in transform domains. bioRxiv [Preprint]. 2023 Nov 27:2023.11.21.568193. doi: 10.1101/2023.11.21.568193. PMID: 38076916. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-06-012