302-02-003 ISMRM Abstract

Categorical 1H VOLVE Lung MRI Quantifies Ventilation Magnitude and Delay in Cystic Fibrosis and CFTR Modulator Response

Primary: Body - Lung

Secondary: Analysis Methods - Visualization

302-02-003 · Take a Breath: Chest, Thoracic, and Pulmonary MRI · Monday, 11 May, 8:20 AM–10:10 AM · Hall 1B

Keywords: Treatment Response Lung Quantitative Imaging Ventilation

Accepted

Zachary Peggs ^1,2, Jonathan Brooke^2,3, Christabella Ng^2,4, Alexander Yule^2,3, Andrew Prayle^2,4, Helen Barr^2,3,4,5, Charlotte E Bolton^2,3,4, Alan R Smyth⁶, Ian P Hall^2,3,4, Penny Gowland^1,2, Susan Francis^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

²NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom

³Respiratory Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

⁴School of Medicine, University of Nottingham, Nottingham, United Kingdom

⁵Wolfson Cystic Fibrosis Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

⁶School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom

Presenting Author: Zachary Peggs

Synopsis

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References

1. M. Dohna et al., “PREFUL MRI for Monitoring Perfusion and Ventilation Changes after Elexacaftor-Tezacaftor-Ivacaftor Therapy for Cystic Fibrosis: A Feasibility Study,” Radiol Cardiothorac Imaging, vol. 6, no. 2, Apr. 2024, doi: 10.1148/RYCT.230104. [doi]

2. F. Klimeš et al., “Effect of CFTR modulator therapy with elexacaftor/tezacaftor/ivacaftor on pulmonary ventilation derived by 3D phase-resolved functional lung MRI in cystic fibrosis patients,” Eur Radiol, vol. 34, no. 1, pp. 80–89, Jan. 2024, doi: 10.1007/S00330-023-09912-6. [doi]

3. Z. J. T. Peggs, J. P. Brooke, C. E. Bolton, I. P. Hall, S. T. Francis, and P. A. Gowland, “Free-Breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-Wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients With Chronic Obstructive Pulmonary Disease,” Journal of Magnetic Resonance Imaging, vol. 61, no. 2, pp. 663–675, Feb. 2025, doi: 10.1002/JMRI.29444. [doi]

4. J. Glandorf et al., “Comparison of phase-resolved functional lung (PREFUL) MRI derived perfusion and ventilation parameters at 1.5T and 3T in healthy volunteers,” PLoS One, vol. 15, no. 12, p. e0244638, Dec. 2020, doi: 10.1371/JOURNAL.PONE.0244638. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/302-02-003