Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-01-007 ISMRM Abstract

FRONTO-PARIETAL CINGULUM WHITE MATTER CHANGES IN DOWN SYNDROME: CROSS-SECTIONAL AND LONGITUDINAL DIFFUSION MR TRACTOGRAPHY

Primary: Neuro - Alzheimer's Disease
Secondary: Neuro - White Matter
566-01-007 · Detectable Changes in Dementia · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row G
Keywords: Aging Alzheimer's Disease Tractography White Matter Down Syndrome
Accepted
Phoebe F Ivain 1, Fedal Saini1, Mina Idris1, Leda Bianchi1, Andre Strydom1, Flavio Dell'Acqua1
1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Presenting Author: Phoebe F Ivain

Synopsis

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References

1. McCarron M, McCallion P, Reilly E, Mulryan N. A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome. J Intellect Disabil Res. 2014;58(1):61-70.
2. McCarron M, McCallion P, Reilly E, Dunne P, Carroll R, Mulryan N. A prospective 20-year longitudinal follow-up of dementia in persons with Down syndrome. J Intellect Disabil Res. 2017;61(9):843-852.
3. Bubb EJ, Metzler-Baddeley C, Aggleton JP. The cingulum bundle: Anatomy, function, and dysfunction. Neurosci Biobehav Rev. 2018;92:104-127.
4. Saini F, Dell'Acqua F, Strydom A. Structural Connectivity in Down Syndrome and Alzheimer's Disease. Front Neurosci. 2022;16:908413.
5. Dell’Acqua F, Beyh A, Stones R, et al. MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets. bioRxiv. 2025:2025.2005.2027.656234.
6. Davidson YS, Robinson A, Prasher VP, Mann DMA. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta Neuropathol Commun. 2018;6(1):56.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-01-007