Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-005 ISMRM Abstract

Multimodal MRI Evaluation of Glymphatic System Function in Patients with Temporal Lobe Epilepsy

Accepted
Zhuo Wang1, Guangxu Han2, Jinqin Li1, Dengyan Song1, Hao Ye1, Yuanyuan wei1, Bing Chen 3
1The First Clinical Medical College of Ningxia Medical University, Yinchuan, China
2GE HealthCare MR Research, Beijing, China
3General Hospital of Ningxia Medical University, Yinchuan, China
Presenting Author: Bing Chen

Synopsis

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References

1. WANG J, XIA X, ZHANG B, et al. Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy [J]. Front Aging Neurosci, 2024, 16: 1459580.
2. LEE D A, KO J, KIM S T, et al. The association between structural connectivity and anti-seizure medication response in patients with temporal lobe epilepsy [J]. Epilepsia Open, 2024, 9(6): 2408-18.
3. XIE F, ZHOU C, JIN H, et al. Bilateral glymphatic dysfunction and its association with disease duration in unilateral temporal lobe epilepsy patients with hippocampal sclerosis [J]. Epilepsy & behavior : E&B, 2024, 155: 109777.
4. TAOKA T, MASUTANI Y, KAWAI H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases [J]. Japanese journal of radiology, 2017, 35(4): 172-8.
5. LI Y, ZHU Z, CHEN J, et al. Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson's Disease [J]. Front Aging Neurosci, 2020, 12: 161.
6. QIN Y, LI X, QIAO Y, et al. DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke [J]. Front Neurosci, 2023, 17: 1132393.
7. LAURENT A, ARTIGES E, MELLERIO C, et al. Metabolic correlates of cognitive impairment in mesial temporal lobe epilepsy [J]. Epilepsy & behavior : E&B, 2020, 105: 106948.
8. ZHANG Y, HUANG G, GENG J, et al. DTI-ALPS index-assessed glymphatic dysfunction mediates Alzheimer's cognitive decline via amyloid-β-dependent pathways: multimodal PET/MRI study [J]. European journal of nuclear medicine and molecular imaging, 2025.
9. KURODA T, HONMA M, MORI Y, et al. Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer's Disease [J]. Front Aging Neurosci, 2020, 12: 13.
10. SCHEFFER I E, BERKOVIC S, CAPOVILLA G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology [J]. Epilepsia, 2017, 58(4): 512-21.
11. FISCHL B. FreeSurfer [J]. NeuroImage, 2012, 62(2): 774-81.
12. JENKINSON M, BECKMANN C F, BEHRENS T E, et al. FSL [J]. NeuroImage, 2012, 62(2): 782-90.
13. TOURNIER J D, SMITH R, RAFFELT D, et al. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation [J]. NeuroImage, 2019, 202: 116137.
14. WANG D J J, GREENBERG S M, HELMER K G, et al. Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function [J]. Aging and disease, 2023.

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