Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
304-04-007 ISMRM Abstract

Cross-species fMRI signature of Locus Coeruleus-driven brain state transitions

Primary: Brain Function and fMRI - Functional Connectivity
Secondary: Brain Function and fMRI - fMRI & Neuromodulation
304-04-007 · Multimodal and Innovative Design · Monday, 11 May, 4:10 PM–6:00 PM · Ballroom East
Keywords: fMRI (resting state) Preclinical image analysis Translational Studies fMRI Analysis Functional magnetic resonance imaging
Accepted
Francesca Barcellini 1,2,3, Georgios Foustoukos4, Daniel Wenz3, Brandon Munn5, James M Shine5, Laura M Fernandez4, Anita Luthi4, Valerio Zerbi2
1Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
2Departments of Psychiatry and Basic Neuroscienc, Université de Genève, Genève, Switzerland
3Center for Biomedical Imaging (CIBM), Lausanne, Switzerland
4Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
5Brain and Mind Center, The University of Sydney, Sydney, Australia
Presenting Author: Francesca Barcellini

Synopsis

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References

1. 1. Shine JM, Aburn MJ, Breakspear M, Poldrack RA. The modulation of neural gain facilitates a transition between functional segregation and integration in the brain. eLife. 2018;7:e31130. DOI:10.7554/eLife.31130 [doi]
2. Zhang, Y., Rózsa, M., Liang, Y. et al. Fast and sensitive GCaMP calcium indicators for imaging neural populations. Nature 615, 884–891 (2023). https://doi.org/10.1038/s41586-023-05828-9 [doi]
3. Grimm C et al. Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy. Nat Neurosci. 2024;27:2167-2177. DOI: 10.1038/s41593-024-01755-8 [doi]
4. Yu Y et al. Sleep fMRI with simultaneous electrophysiology in mice. Nat Commun 2023; 14: 1651. doi: 10.1038/s41467-023-37352-9 [doi]
5. Horikawa T et al. Neural decoding of visual imagery during sleep. Science. 2013;340:639-642. DOI: 10.1126/science.1234330 [doi]
6. Balsters JH et al. Primate homologs of mouse cortico-striatal circuits. eLife. 2020;9:e53680. DOI: 10.7554/eLife.53680 [doi]
7. Osorio-Forero A et . Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle. Nat Neurosci. 2025;28(1):84-96. DOI: 10.1038/s41593-024-01822-0 [doi]
8. Hobson JA, Pace-Schott EF. The cognitive neuroscience of sleep: neuronal systems, consciousness, and learning. Nat Rev Neurosci 2002; 3: 679-693. DOI: 10.1038/nrn915 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/304-04-007