Synopsis
Motivation:
Goals:
Approach:
Results:
470-05-106
ISMRM Abstract
Intra- and extra-axonal structural disorder in a rat model of mild traumatic brain injury using time-dependent Standard Model
Accepted
Full abstract & presentation
The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.
Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.
To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.
Log inReferences
1. Ohgami, T., Kitamoto, T., Tateishi, J. Alzheimer’s amyloid precursor protein accumulates within axonal swellings in human brain lesions, Neuroscience Letters, 136, 75 (1992).
2. Kim-Han, J. S., Antenor-Dorsey, J. A., O’Malley, K. L. The Parkinsonian Mimetic, MPP+, Specifically Impairs Mitochondrial Transport in Dopamine Axons, The Journal of Neuroscience 31, 7212 (2011).
3. Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mork, S., Bo, L. Axonal Transection in the Lesions of Multiple Sclerosis, New England Journal of Medicine 338, 278 (1998).
4. Tang-Schomer, M. D., Johnson, V. E., Baas, P. W., Stewart, W., Smith, D. H. Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury, Experimental Neurology 233, 364 (2012).
5. Shepherd, G. M. G., Raastad, M., Andersen, P. General and variable features of varicosity spacing along unmyelinated axons in the hippocampus and cerebellum, Proceedings of the National Academy of Sciences 99, 6340 (2002).
6. Geula, C., Nagykery, N., Nicholas, A., Wu, C.-K. Cholinergic Neuronal and Axonal Abnormalities Are Present Early in Aging and in Alzheimer Disease, Journal of Neuropathology & Experimental Neurology 67, 309 (2008).
7. Novikov, D. S., Jensen, J.H., Helpern, J.A., Fieremans, E. Revealing mesoscopic structural universality with diffusion. PNAS, 111(14) (2014).
8. Burcaw, L.M., Fieremans, E., and Novikov, DS. Mesoscopic structure of neuronal tracts from time-dependent diffusion. NeuroImage 114 (2015).
9. Novikov, D. S., Fieremans, E., Jespersen, S. N., Kiselev, V. G. Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation, NMR in Biomedicine 32 (2019).
10. Lee, HH., Papaioannou, A., Novikov, D.S., Fieremans, E. In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter. NeuroImage 222 (2020)
11. Dhital, B., Reisert, M., Kellner, E., Kiselev, VG. Intra-axonal diffusivity in brain white matter. Neuroimage 189 (2019)
12. Fieremans, E., et al. In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter. NeuroImage, 129 (2016).
13. Jespersen, S.N., Olesen, J.L., Hansen, B., Shemesh, N. Diffusion time dependence of microstructural parameters in fixed spinal cord, NeuroImage 182 (2018)
14. Lee, HH, Papaioannou, A., Kim, S.-L., Novikov, D. S., Fieremans, E. A time-dependent diffusion MRI signature of axon caliber variations and beading, Communications Biology 3, 354 (2020).
15. Tan, E. T., Shih, R. Y., Mitra, J., Sprenger, T., Hua, Y., Bhushan, C., Bernstein, M. A., McNab, J. A., DeMarco, J. K., Ho, V. B., Foo, T. K. Oscillating diffusion encoding with a high gradient-amplitude and high slew rate head-only gradient for human brain imaging, Magnetic Resonance in Medicine 84, 950 (2020).
16. Arbabi, A., Kai, J., R. Khan, A., Baron, C. A., Diffusion dispersion imaging: Mapping oscillating gradient spin-echo frequency dependence in the human brain, Magnetic Resonance in Medicine 83, 2197 (2020).
17. Abdollahzadeh, A., Coronado-Leija, R., Lee, HH., Sierra, A., Fieremans, E., Novikov, D. S. Scattering approach to diffusion quantifies axonal damage in brain injury, https://doi.org/10.48550/arXiv.2501.18167, to appear in Nature Communications DOI: 10.1038/s41467-025-64793-1. [doi]
18. Lee HH, Fieremans, E., Novikov, D. S., Novikov, D. S. LEMONADE (t): exact relation of time-dependent diffusion signal moments to neuronal microstructure, Proc Intl Soc Mag Reson Med 26, 884
19. Novikov, D. S., Veraart, J., Jelescu, I. O. & Fieremans, E. Rotationally-invariant mapping of scalar and orientational metrics of neuronal microstructure with diffusion MRI, NeuroImage 174 (2018).
20. Reisert, M., Kellner, E., Dhital, B., Hennig, J. & Kiselev, V. G. Disentangling micro from mesostructure by diffusion MRI: A Bayesian approach. NeuroImage 147, 964-975, (2017).
21. Molina I. S. M., Salo, R. A., Abdollahzadeh, A., Tohka, J., Grohn, O., Sierra, A., In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats, eNeuro 7, 1 (2020).79
22. Abdollahzadeh, A., Belevich, I., Jokitalo, E., Sierra, A., Tohka, J., DeepACSON Automated Segmentation of White Matter in 3D Electron Microscopy, Communications Biology 4, 179
23. Chen, J., Ades-Aron, B., Lee, HH, Mehrin, S., Pang, M., Novikov, D. S., Veraart, J., Fieremans, E. Optimization and validation of the DESIGNER preprocessing pipeline for clinical diffusion MRI in white matter aging, Imaging Neuroscience 2, 1 (2024).
24. Chan, K.-S., Ma, Y., Lee, H., Marques, J.P., Olesen, J.L., Coelho, S., Novikov, D.S., Jespersen, S.N., Huang, S.Y., Lee, H.-H., 2025. In vivo human neurite exchange time imaging at 500 mT/m diffusion gradients. Imaging Neurosci. 3, imag_a_00544.
Cite this abstract
http://echo.ismrm.org/p/ISMRM2026/470-05-106