Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-01-004 / 552-01-004 ISMRM Abstract

In Vivo Characterization of the Redox Balance in IDH-Wildtype Glioblastomas using J-difference Edited MEGA-sLASER MRS at 3T

Primary: Neuro - Tumors
Secondary: Contrast Mechanisms - Spectroscopy
552-01-004 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
552-01-004 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
Keywords: Biomarkers Glioblastoma MR Spectroscopy (MRS) MEGA-sLASER Redox
Accepted
Seyma Alcicek1,2,3,4, Andrei Manzhurtsev1, Dennis C Thomas1,2,3,4, Iris Divé2,3,4,5, Katharina J Weber2,3,4,6, Vincent Prinz7, Daniel Jussen7, Dinesh K Deelchand8, Georg Oeltzschner9, Michael Ronellenfitsch2,3,4,5, Joachim P Steinbach2,3,4,5, Elke Hattingen1,2,3,4, Ulrich Pilatus1, Katharina Wenger 1,2,3,4
1Goethe University, University Hospital Frankfurt, Institute of Neuroradiology and Cooperative Brain Imaging Center - CoBIC, Frankfurt am Main, Germany
2University Cancer Center Frankfurt (UCT), Frankfurt am Main, Germany
3Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany
4German Cancer Research Center (DKFZ) Heidelberg, Germany and German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany
5Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
6Institute of Neurology (Edinger-Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
7Department of Neurosurgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
8Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, United States of America
9The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
Presenting Author: Katharina Wenger

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Wen PY, Weller M, Lee EQ, et al. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020;22(8):1073-1113. doi:10.1093/neuonc/noaa106 [doi]
2. Ruiz‐Rodado V, Dowdy T, Lita A, et al. Cysteine is a limiting factor for glioma proliferation and survival. Mol Oncol. 2022;16(9):1777-1794. doi:10.1002/1878-0261.13148 [doi]
3. Campos-Sandoval JA, Gómez-García MC, Santos-Jiménez J de los, Matés JM, Alonso FJ, Márquez J. Antioxidant responses related to temozolomide resistance in glioblastoma. Neurochemistry International. 2021;149:105136. doi:10.1016/j.neuint.2021.105136 [doi]
4. Andreychenko A, Boer VO, Arteaga de Castro CS, Luijten PR, Klomp DWJ. Efficient spectral editing at 7 T: GABA detection with MEGA-sLASER. Magn Reson Med. 2012;68(4):1018-1025. doi:10.1002/mrm.24131 [doi]
5. Alcicek S, Manzhurtsev A, Ronellenfitsch MW, Deelchand D, Steinbach JP, Prinz, V. In vivo detection of GSH and GABA in high-grade glioma using MEGA-sLASER spectral editing at 3 T. Proc Intl Soc Magn Reson Med. 2024;32:0361.
6. Edden RAE, Puts NAJ, Harris AD, Barker PB, Evans CJ. Gannet: A Batch-Processing Tool for the Quantitative Analysis of Gamma-Aminobutyric Acid–Edited MR Spectroscopy Spectra. J Magn Reson Imaging. 2014;40(6):1445-1452. doi:10.1002/jmri.24478 [doi]
7. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine. 1993;30(6):672-679. doi:10.1002/mrm.1910300604 [doi]
8. Kofler F, Berger C, Waldmannstetter D, et al. BraTS Toolkit: Translating BraTS Brain Tumor Segmentation Algorithms Into Clinical and Scientific Practice. Front Neurosci. 2020;14. doi:10.3389/fnins.2020.00125 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-01-004