Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-02-009 ISMRM Abstract

Intrinsic CSF Outflow: MRI evidence for Distinct Flow Mechanisms

Primary: Neuro - Development
Secondary: Neuro - Neurofluids
406-02-009 · The Dynamic Brain: Flow, Pressure, and Exchange · Tuesday, 12 May, 1:40 PM–3:30 PM · Auditorium 2
Keywords: Glymphatic system Cerebrospinal fluid
Accepted
Vadim Malis 1, Mitsue MIYAZAKI2
1University of California, San Diego, United States of America
2Radiology, University of California, San Diego, United States of America
Presenting Author: Vadim Malis

Synopsis

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References

1. Iliff JJ, Wang M, Liao Y, et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci Transl Med. 2012;4(147):147ra111. doi:10.1126/scitranslmed.3003748 [doi]
2. Kress BT, Iliff JJ, Xia M, et al. Impairment of paravascular clearance pathways in the aging brain. Ann Neurol. 2014;76(6):845-861. doi:10.1002/ana.24271 [doi]
3. Yamada S, Miyazaki M, Kanazawa H, et al. Visualization of Cerebrospinal Fluid Movement with Spin Labeling at MR Imaging: Preliminary Results in Normal and Pathophysiologic Conditions. Radiology. 2008;249(2):644-652. doi:10.1148/radiol.2492071985 [doi]
4. Malis V, Bae WC, Yamamoto A, McEvoy LK, McDonald MA, Miyazaki M. Age-related Decline of Intrinsic Cerebrospinal Fluid Outflow in Healthy Humans Detected with Non-contrast Spin-labeling MR Imaging. Magn Reson Méd Sci. 2024;23(1):66-79. doi:10.2463/mrms.mp.2022-0117 [doi]
5. Miyazaki M, Malis V, Yamamoto A, et al. Physical Exercise Alters Egress Pathways for Intrinsic CSF Outflow: An Investigation Performed with Spin-labeling MR Imaging. Magn Reson Méd Sci. 2024;23(2):171-183. doi:10.2463/mrms.mp.2023-0005 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/406-02-009