Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-05-009 Registered Abstract

Lac/NAA Ratio Threshold Using sLASER-144 Single-Voxel MRS and ADC Scores in Neonates with Hypoxic-Ischemic Encephalopathy

Primary: Pediatrics - Neuro
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
562-05-009 · Fetal and Neonatal Imaging · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row C
Keywords: Neonatal Hypoxic-ischemic encephalopathy Lactate Semi-LASER ADC
Accepted
Hennie Y Kuipers 1, Martine C Lagerweij1, Jochen A.C. van Osch1, Isabell K Steinseifer1, Leo Kluijtmans2, Laura de Jong3, Martijn F Boomsma2, Susanne Mulder-de Tollenaer4
1Medical Physics, Isala Hospital, Zwolle, Netherlands
2Radiology, Isala Hospital, Zwolle, Netherlands
3Radiology, Wilhelmina Ziekenhuis, Assen, Netherlands
4Neonatology, Isala Hospital, Zwolle, Netherlands
Presenting Author: Hennie Y Kuipers

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References

1. Groenendaal F, Casaer A, Dijkman KP, et al. Introduction of hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders. Neonatology. 2013;104(1):15-21.
2. Wu T-W, Tamrazi B, Hsu K-H, Ho E, Reitman AJ, Borzage M, Blüml S, Wisnowski JL. Cerebral lactate concentration in neonatal hypoxic-ischemic encephalopathy: in relation to time, characteristic of injury, and serum lactate concentration. Front Neurol. 2018;9:293.
3. Guo L, Wang D, Bo G, Zhang H, Tao W, Shi Y. Early identification of hypoxic-ischemic encephalopathy by combination of magnetic resonance imaging and proton MR spectroscopy. Exp Ther Med. 2016;12(5):2835-42.
4. Alderliesten T, et al. MRI and spectroscopy in (near) term neonates with perinatal asphyxia and therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed. 2016;0:F1-F6.
5. Dacko M, Lange T. Improved detection of lactate and β-hydroxybutyrate using MEGA-sLASER at 3 T. NMR Biomed. 2019;32:e4100.
6. Mitra S, Kendall GS, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, Robertson NJ. Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed. 2019;104:F424–F432.
7. Lally PJ, Pauliah SS, Montaldo P, Olson L, Bainbridge A, Mendoza J, et al. Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study. Lancet Neurol. 2019;18(1):35–45.
8. Ouwehand S, Smidt LCA, Dudink J, Benders MJNL, de Vries LS, Groenendaal F, van der Aa NE. Predictors of outcomes in hypoxic-ischemic encephalopathy following hypothermia: a meta-analysis. Neonatology. 2020;117(4):411–427.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/562-05-009