Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
530-03-006 ISMRM Abstract

Intralaminar Thalamic Recruitment Predicts Clinical Benefit after MRgFUS Thalamotomy for Essential Tremor

Primary: Interventional - MR-Guided Focused Ultrasound
Secondary: Neuro - Neuromodulation
530-03-006 · Interventional MRI: Tracking, Temperature Mapping, and Image-Guided Therapy · Wednesday, 13 May, 1:40 PM–3:30 PM · Meeting Room 2.60
Keywords: fMRI (resting state) Focused Ultrasound Interventional Devices Longitudinal study Movement Disorder
Accepted
Darren L Clark 1, Conrad P Rockel1, Samuel Pichardo1, Camila Aquino1, Davide Martino2, Tejas Sankar3, Fady Girgis1, Zelma H Kiss2, Bruce Pike2,4,5,6
1Radiology and Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
2Department of Clinical Neuroscience, University of Calgary, Calgary, Canada
3Division of Neurology, Department of Medicine, and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada, Canada
4University of Calgary, Calgary, Canada
5Department of Radiology, University of Calgary, Calgary, Canada
6Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
Presenting Author: Darren L Clark

Synopsis

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References

1. Elias, W. J. et al. A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor. N. Engl. J. Med. 375, 730–739 (2016). PMID: 27557301 [pmid]
2. Elias, W. J. et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N. Engl. J. Med. 369, 640–648 (2013). PMID: 23944301 [pmid]
3. Park, Y.-S., Jung, N. Y., Na, Y. C. & Chang, J. W. Four-year follow-up results of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov. Disord. Off. J. Mov. Disord. Soc. 34, 727–734 (2019). PMID: 30759322 [pmid]
4. Clark DL, Rockel C, Pichardo S, Sankar T, Girgis F, Aquino C, Martino D, Kiss ZHT, and Pike GB. Acute versus chronic ventral lateral thalamus intrinsic connectivity after MR-guided focused ultrasound thalamotomy for essential tremor. in Proceedings of Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition. (Singapore, 2024).
5. Kumar, V. J., Scheffler, K. & Grodd, W. The structural connectivity mapping of the intralaminar thalamic nuclei. Sci. Rep. 13, 11938 (2023). PMID: 37488187 [pmid]
6. Fahn S, Tolosa E, Marin C. Clinical rating Scale for Tremor. in Parkinson’s Disease and Movement Disorders. 225–234 (Munich: Urban & Scharzenberg, 1988).
7. Whitfield-Gabrieli, S. & Nieto-Castanon, A. Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect. 2, 125–141 (2012). PMID: 22642651 [pmid]
8. Penny, W. D., Stephan, K. E., Mechelli, A. & Friston, K. J. Modelling functional integration: a comparison of structural equation and dynamic causal models. NeuroImage 23 Suppl 1, S264-274 (2004) PMID: 15501096 [pmid]
9. Jakab, A., Blanc, R., Berényi, E. L. & Székely, G. Generation of individualized thalamus target maps by using statistical shape models and thalamocortical tractography. AJNR Am. J. Neuroradiol. 33, 2110–2116 (2012). PMID: 22700756 [pmid]
10. Krauth, A. et al. A mean three-dimensional atlas of the human thalamus: generation from multiple histological data. NeuroImage 49, 2053–2062 (2010). PMID: 19853042 [pmid]

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http://echo.ismrm.org/p/ISMRM2026/530-03-006