Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
608-01-004 ISMRM Abstract

The Effect of Statin and PCSK9 Inhibitor Combination Therapy on Plaque Stability in Intracranial Atherosclerotic Stenosis

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Neuro - Blood Vessels
608-01-004 · Vessel Wall Imaging · Thursday, 14 May, 8:30 AM–10:20 AM · Meeting Room 1.60
Keywords: High-Resolution MRI Vascular Plaques Atherosclerotic stenosis PCSK9 inhibitors Therapy
Accepted
Ming yu Zhou 1, Peng xin Hu1, Yu Zou1, Cong Cao1, Jiankun Dai2, Xiaoping Tang1
1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
2MR Research, Beijing, China
Presenting Author: Ming yu Zhou

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References

1. Gutierrez J, Turan T N, Hoh B L, et al. Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment[J]. Lancet Neurol., 2022, 21(4): 355–368. DOI:10.1016/S1474-4422(21)00376-8. [doi]
2. Shah J, Liu S, Yu W. Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines[J]. Stroke Vasc. Neurol., 2022, 7(5): 406–414. DOI:10.1136/svn-2021-001166. [doi]
3. Nicholls S J, Kataoka Y, Nissen S E, et al. Effect of evolocumab on coronary plaque phenotype and burden in statin-treated patients following myocardial infarction[J]. JACC Cardiovasc. Imaging, 2022, 15(7): 1308–1321. DOI:10.1016/j.jcmg.2022.03.002. [doi]
4. Ota H, Omori H, Kawasaki M, et al. Clinical impact of PCSK9 inhibitor on stabilization and regression of lipid-rich coronary plaques: a near-infrared spectroscopy study[J]. Eur. Heart J. Cardiovasc. Imaging, 2022, 23(2): 217–228. DOI:10.1093/ehjci/jeab034. [doi]
5. Ma X, Yan P, Ju J, et al. Vessel wall MRI characteristics associated with intraprocedural stent thrombosis during angioplasty for intracranial atherosclerotic stenosis[J]. J. Neurointerventional Surg., 2024, 16(12): 1348–1352. DOI:10.1136/jnis-2023-020941. [doi]
6. Chung J-W, Cha J, Lee M J, et al. Intensive statin treatment in acute ischaemic stroke patients with intracranial atherosclerosis: a high-resolution magnetic resonance imaging study (STAMINA-MRI study)[J]. J. Neurol. Neurosurg. Psychiatry, 2020, 91(2): 204–211. DOI:10.1136/jnnp-2019-320893. [doi]
7. Taylor B A, Thompson P D. Statins and their effect on PCSK9-impact and clinical relevance[J]. Curr. Atheroscler. Rep., 2016, 18(8): 46. DOI:10.1007/s11883-016-0604-3. [doi]
8. Yang D, Liu J, Yao W, et al. The MRI enhancement ratio and plaque steepness may be more accurate for predicting recurrent ischemic cerebrovascular events in patients with intracranial atherosclerosis[J]. Eur. Radiol., 2022, 32(10): 7004–7013. DOI:10.1007/s00330-022-08893-2. [doi]

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http://echo.ismrm.org/p/ISMRM2026/608-01-004