469-05-007 ISMRM Abstract

¹³C-lactate imaging without hyperpolarization using Selective Polarization Transfer (SPT) / NOE CSI-SSFP experiments

Primary: Contrast Mechanisms - Non-Proton

Secondary: Contrast Mechanisms - Spectroscopy

469-05-007 · Non-Proton MRI: Methods and Applications · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row J

Keywords: Deuterium Metabolic Imaging Lactate Hyperpolarized 13C MRI Metabolic imaging SSFP

Accepted

Elton T Montrazi ¹, Lucio Frydman²

¹Weizmann Institute, Rehovot, Israel

²Weismann Institute, Israel

Presenting Author: Elton T Montrazi

Synopsis

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References

1. Lu M, Chen W, et al., Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 2017 PMID: 28503999. [pmid]

2. De Feyter HM, de Graaf RA, et al., Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv. 2018 PMID: 30140744. [pmid]

3. de Graaf RA, Hendriks AD, Klomp DWJ, Kumaragamage C, Welting D, Arteaga de Castro CS, Brown PB, McIntyre S, Nixon TW, Prompers JJ, De Feyter HM. On the magnetic field dependence of deuterium metabolic imaging. NMR Biomed. 2020 Mar;33(3):e4235. doi: 10.1002/nbm.4235. Epub 2019 Dec 26. PMID: 31879985; PMCID: PMC7141779. [doi] [pmid]

4. Peters DC, Frydman L, et al., Improving deuterium metabolic imaging (DMI) signal-to-noise ratio by spectroscopic multi-echo bSSFP: A pancreatic cancer investigation. Magn Reson Med. 2021 PMID: 34196041. [pmid]

5. Montrazi ET, Frydman L, et al., Deuterium imaging of the Warburg effect at sub-millimolar concentrations by joint processing of the kinetic and spectral dimensions. NMR Biomed. 2023 PMID: 37401393. [pmid]

6. Montrazi ET, Frydman L, et al., High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models. Sci Rep. 2023 PMID: 37968574. [pmid]

7. Montrazi ET, Frydman L, et al., Molecular imaging of tumor metabolism: Insight from pyruvate- and glucose-based deuterium MRI studies. Sci Adv. 2024 PMID: 38478615. [pmid]

8. Aleksis R, Montrazi ET, Frydman L. Heteronuclear Polarization Transfer under Steady-State Conditions: The INEPT-SSFP Experiment. J Phys Chem Lett. 2024 PMID: 39412220. [pmid]

9. Pachler KGR, Wessels PL. Selective population inversion (Spi) – pulsed double-resonance method in FT NMR-spectroscopy equivalent to indor. J. Magn. Reson. 1973;12:337–339. doi: 10.1016/0022-2364(73)90120-0. [doi]

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http://echo.ismrm.org/p/ISMRM2026/469-05-007