Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-03-009 ISMRM Abstract

Structure-Function Coupling: A Prognostic Biomarker for Motor Recovery after Stroke

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Diffusion - Diffusion Analysis & Visualization
406-03-009 · fMRI: Applications in Neurology · Tuesday, 12 May, 4:00 PM–5:50 PM · Auditorium 2
Keywords: Motor function Imaging biomarkers Prediction Structural-Functional Coupling
Accepted
Yuming Zhong 1, Yan Wang2, Chetwyn C CHAN3, Kenneth Fong4,5, Sai Kam Hui1,6
1CU Lab of AI in Radiology (CLAIR), Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China
2The University of Hong Kong, Hong Kong, Hong Kong
3Department of Psychology, The Education University of Hong Kong, Hong Kong
4Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
5Research Centre for Assistive Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
6Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China
Presenting Author: Yuming Zhong

Synopsis

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References

1. He Q, Wang W, Zhang Y, et al. Global, Regional, and National Burden of Stroke, 1990–2021: A Systematic Analysis for Global Burden of Disease 2021. Stroke. 2024;55(12):2815-2824. doi:10.1161/STROKEAHA.124.048033 [doi]
2. Ntaios G, Gioulekas F, Papavasileiou V, Strbian D, Michel P. ASTRAL, DRAGON and SEDAN scores predict stroke outcome more accurately than physicians. Eur J Neurol. 2016;23(11):1651-1657. doi:10.1111/ene.13100 [doi]
3. Espenhahn S, Rossiter HE, van Wijk BCM, et al. Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke. Accessed October 28, 2025. https://dx.doi.org/10.1093/braincomms/fcaa161 [doi]
4. Cassidy JM, Mark JI, Cramer SC. Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation. Accessed October 28, 2025. https://dx.doi.org/10.1093/brain/awab469 [doi]
5. Salvalaggio S, Gambazza S, Andò M, et al. Modeling Upper Limb Rehabilitation-Induced Recovery After Stroke: The Role of Attention as a Clinical Confounder. Phys Ther. 2025;105(2):pzae148. doi:10.1093/ptj/pzae148 [doi]
6. Moulton E, Magno S, Valabregue R, et al. Acute Diffusivity Biomarkers for Prediction of Motor and Language Outcome in Mild-to-Severe Stroke Patients. Stroke. 2019;50(8):2050-2056. doi:10.1161/STROKEAHA.119.024946 [doi]
7. Preti MG, Van De Ville D. Decoupling of brain function from structure reveals regional behavioral specialization in humans. Nat Commun. 2019;10(1):4747. doi:10.1038/s41467-019-12765-7 [doi]
8. Fotiadis P, Parkes L, Davis KA, Satterthwaite TD, Shinohara RT, Bassett DS. Structure–function coupling in macroscale human brain networks. Nat Rev Neurosci. 2024;25(10):688-704. doi:10.1038/s41583-024-00846-6 [doi]

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http://echo.ismrm.org/p/ISMRM2026/406-03-009