Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
507-03-010 ISMRM Abstract

In Vivo Human Brain CEST MRI at 11.7T: First Results

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Physics & Engineering - High-Field MRI
507-03-010 · New Frontiers in CEST MRI · Wednesday, 13 May, 1:40 PM–3:30 PM · Meeting Room 1.40
Keywords: CEST / APT / NOE Ultra-high field PTx CEST MRI
Accepted
Camélia Ressam 1, Joseph Brégeat1, Alfredo L Lopez Kolkovsky1, Alexis S Amadon1, Alexandre Vignaud1, Aurélien Massire2, Son Chu3, Shajan Gunamony3, Nicolas Boulant1, Vincent Gras1, Franck Mauconduit1, Luisa Ciobanu1
1CEA NeuroSpin, Paris-Saclay University, CNRS, Gif-Sur-Yvette, France
2Siemens Healthcare SAS, Courbevoie, France
3Imaging Centre of Excellence, University of Glasgow, Glasgow, United Kingdom
Presenting Author: Camélia Ressam

Synopsis

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References

1. Delebarre, T. et al. Efficient optimization of chemical exchange saturation transfer MRI at 7 T using universal pulses and virtual observation points. Magn. Reson. Med. 90, 51–63 (2023). doi: 10.1002/mrm.29617. [doi]
2. Eichfelder, G. & Gebhardt, M. Local specific absorption rate control for parallel transmission by virtual observation points. Magn. Reson. Med. 66, 1468–1476 (2011). doi: 10.1002/mrm.22927. [doi]
3. Schmitz-Abecassis, B., Najac, C., Plugge, J., van Osch, M. J. P. & Ercan, E. Investigation of metabolite correlates of CEST in the human brain at 7 T. NMR Biomed. 37, e5104 (2024). doi: 10.1002/nbm.5104. [doi]
4. Hadar, P. N. et al. Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study. Brain Behav. 11, e02134 (2021). doi: 10.1002/brb3.2134. [doi]
5. Boulant, N. et al. In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner. Nat. Methods 1–4 (2024) doi:10.1038/s41592-024-02472-7. [doi]
6. Chu, S. et al. An 8-Channel Transmit Array in Combination with a 31-Channel Receive Array for Human Brain Imaging at 11.7T. #1415 (ISMRM, Singapour, 2024). doi:10.58530/2024/1415. [doi]
7. Ressam, C., Gras, V., Mauconduit, F. & Ciobanu, L. CEST perspectives for human brain applications at 11.7 T. #2020 (ISMRM, Honolulu, Hawaii, USA, 2025). doi:10.58530/2025/2020. [doi]
8. Kim, M., Gillen, J., Landman, Bennett. A., Zhou, J. & van Zijl, P. C. M. WAter Saturation Shift Referencing (WASSR) for chemical exchange saturation transfer experiments. Magn. Reson. Med. 61, 1441–1450 (2009). doi: 10.1002/mrm.21873. [doi]
9. Setsompop, K. et al. Slice-selective RF pulses for in vivo B inhomogeneity mitigation at 7 tesla using parallel RF excitation with a 16-element coil. Magn. Reson. Med. 60, 1422–1432 (2008). doi: 10.1002/mrm.21739. [doi]
10. Jenkinson, M., Bannister, P., Brady, M. & Smith, S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. NeuroImage 17, 825–841 (2002). doi: 10.1016/s1053-8119(02)91132-8. [doi]
11. Andersson, J. L. R., Skare, S. & Ashburner, J. How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. NeuroImage 20, 870–888 (2003). doi: 10.1016/S1053-8119(03)00336-7. [doi]
12. Smith, S. M. et al. Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23, S208–S219 (2004). doi: 10.1016/j.neuroimage.2004.07.051. [doi]
13. Breitling, J. et al. Adaptive denoising for chemical exchange saturation transfer MR imaging. NMR Biomed. 32, e4133 (2019). doi: 10.1002/nbm.4133. [doi]
14. Windschuh, J. et al. Correction of B1-inhomogeneities for relaxation-compensated CEST imaging at 7 T. NMR Biomed. 28, 529–537 (2015). doi: 10.1002/nbm.3283. [doi]
15. Schüre, J.-R., Pilatus, U., Deichmann, R., Hattingen, E. & Shrestha, M. A fast and novel method for amide proton transfer-chemical exchange saturation transfer multislice imaging. NMR Biomed. 34, e4524 (2021). doi: 10.1002/nbm.4524. [doi]
16. Zhang, H. et al. Double-Step R1rho-Based Lorentzian Fitting (DROF): A New CEST Analysis Approach and Its Comparison With Existing Methods. NMR Biomed. 38, e70082 (2025). doi: 10.1002/nbm.70082. [doi]
17. Pan, S. Q. et al. Artificial intelligence in chemical exchange saturation transfer magnetic resonance imaging. Artif. Intell. Rev. 58, 210 (2025). doi: 10.1007/s10462-025-11227-5. [doi]
18. Fabian, M. S. et al. Comprehensive 7 T CEST: A clinical MRI protocol covering multiple exchange rate regimes. NMR Biomed. 37, e5096 (2024). doi: 10.1002/nbm.5096. [doi]

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http://echo.ismrm.org/p/ISMRM2026/507-03-010