Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-06-004 ISMRM Abstract

Microstructural Characterization of Hippocampal Subfields in Midlife APOE e4-Carriers using Soma and Neurite Density Imaging

Primary: Neuro - Alzheimer's Disease
Secondary: Diffusion - Microstructure
362-06-004 · Neuroimaging Biomarkers of Aging, Vascular Health, and Dementia · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row C
Keywords: Alzheimer's Disease Microstructure SANDI model APOE4 Healthy Adults
Accepted
Robert C Davis 1, Bradley G Karat2, Louisa E Wood1, Anne Corbett3, Marco Palombo4, Derek K Jones1, Lucy V Hiscox1
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2The Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, Grossman School of Medicine, New York University, New York, United States of America
3College of Medicine and Health, The University of Exeter, Exeter, United Kingdom
4Cardiff University Brain Research Imaging Centre (CUBRIC), School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
Presenting Author: Robert C Davis

Synopsis

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References

1. Dumurgier, J. and C. Tzourio, Epidemiology of neurological diseases in older adults. Rev Neurol (Paris), 2020. 176(9): p. 642-648.
2. Saddiki, H., et al., Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. PLoS Med, 2020. 17(8): p. e1003289.
3. Vanderlip, C.R. and C.E.L. Stark, APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline. bioRxiv, 2024.
4. Shvetcov, A., et al., APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases. Nature Medicine, 2025. 31(8): p. 2590-2601.S
5. Wadhwani, A.R., et al., Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease. Ann Neurol, 2019. 85(5): p. 726-739.
6. Mole, J.P., et al., APOE-ε4-related differences in left thalamic microstructure in cognitively healthy adults. Sci Rep, 2020. 10(1): p. 19787.
7. Mak, E., et al., APOE ɛ4 exacerbates age-dependent deficits in cortical microstructure. Brain Commun, 2024. 6(1): p. fcad351.
8. Palombo, M., et al., SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI. NeuroImage, 2020. 215: p. 116835.
9. DeKraker, J., et al., Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold. Elife, 2022. 11.
10. ROTECT: Platform for Research Online To Investigate Genetics and Cognition & Ageing. The PROTECT Study 2025 [cited 2025 23/10/2025]; Available from: https://www.cataloguementalhealth.ac.uk/?content=study&studyid=PROTECT.
11. Sterne, J.A.C., D.R. Cox, and G.D. Smith, Sifting the evidence—what's wrong with significance tests? Another comment on the role of statistical methods. BMJ, 2001. 322(7280): p. 226-231.
12. Herranz, N. and J. Gil, Mechanisms and functions of cellular senescence. J Clin Invest, 2018. 128(4): p. 1238-1246.

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http://echo.ismrm.org/p/ISMRM2026/362-06-004